丙型肝炎与胆管丧失
Hepatitis C and bile duct loss.
作者信息
Goldin R D, Patel N K, Thomas H C
机构信息
Department of Histopathology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London.
出版信息
J Clin Pathol. 1996 Oct;49(10):836-8. doi: 10.1136/jcp.49.10.836.
AIM
To assess whether bile duct loss is associated with the bile duct damage induced by chronic hepatitis C.
METHODS
Sections were examined from 171 liver biopsy specimens from patients with chronic hepatitis C, 98 biopsy specimens from patients with chronic hepatitis B, 25 postmortem specimens from patients with no evidence of liver disease, and 23 patients who underwent protocol liver biopsy at the time of cholecystectomy.
RESULTS
The bile duct:portal tract ratio for the hepatitis C group was 0.89, for the hepatitis B group was 0.93 and for the two control groups was 0.96 and 0.90, respectively. The ratio was lower in the hepatitis C group than in the other three. In no case of chronic hepatitis C was the ratio less than 0.60. In the hepatitis C group greater bile duct loss was seen in cirrhotic patients.
CONCLUSIONS
Hepatitis C is associated with bile duct loss and this was related to the stage of the disease. However, in the cases studied this did not reach what is generally considered to be significant (that is, greater than 50% of portal tracts lacking bile ducts). This does not preclude a contributory effect of hepatitis C to bile duct loss in the presence of other risk factors, especially in liver transplant recipients.
目的
评估胆管丧失是否与慢性丙型肝炎所致胆管损伤相关。
方法
对171例慢性丙型肝炎患者的肝活检标本、98例慢性乙型肝炎患者的活检标本、25例无肝病证据患者的尸检标本以及23例胆囊切除术时接受标准肝活检的患者进行切片检查。
结果
丙型肝炎组的胆管与门静脉分支比例为0.89，乙型肝炎组为0.93，两个对照组分别为0.96和0.90。丙型肝炎组的比例低于其他三组。在慢性丙型肝炎患者中，该比例无一例低于0.60。在丙型肝炎组中，肝硬化患者的胆管丧失更为明显。
结论
丙型肝炎与胆管丧失相关，且这与疾病阶段有关。然而，在所研究的病例中，这并未达到通常认为的显著程度（即超过50%的门静脉分支无胆管）。这并不排除在存在其他危险因素时，尤其是在肝移植受者中，丙型肝炎对胆管丧失有促成作用。
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