Walker P, Dussault J H, Hart I R, Langelier P, Szöts F
J Pediatr. 1977 Sep;91(3):400-3. doi: 10.1016/s0022-3476(77)81307-3.
A female infant born to a mother with active Graves disease and a strongly positive LATS developed neonatal thyrotoxicosis. The diagnosis was confirmed rapidly by the markedly elevated filter paper spot T4 (5.45 ng/40 microliter) taken on the fifth day of life as part of the Quebec Screening Program for Neonatal Hypothyroidism. Although the infant's serum was negative for LATS, it reacted strongly (as did the maternal serum) in the lipolytic assay for LATS. This case illustrates the ability of screening programs for neonatal hypothyroidism to detect cases of neonatal thyrotoxicosis and supports the hypothesis that this condition is secondary to the placental transfer of a thyroid-stimulating immunoglobulin.
一名母亲患有活动性格雷夫斯病且长效甲状腺刺激素（LATS）呈强阳性的女婴患上了新生儿甲状腺毒症。作为魁北克新生儿甲状腺功能减退筛查项目的一部分，在出生第五天采集的滤纸血斑T4显著升高（5.45 ng/40微升），迅速确诊了该病。尽管婴儿血清的LATS检测呈阴性，但在LATS的脂解试验中反应强烈（与母亲血清一样）。该病例说明了新生儿甲状腺功能减退筛查项目有能力检测出新生儿甲状腺毒症病例，并支持了这种病症是由促甲状腺免疫球蛋白经胎盘转移所致的假说。
