Maes M, Meltzer H Y
Clinical Research Center for Mental Health, University Department of Psychiatry, Antwerp, Belgium.
Psychiatry Res. 1996 Oct 16;64(3):147-59. doi: 10.1016/s0165-1781(96)02917-4.
Functional alterations in the central serotonergic system, including presynaptic and postsynaptic function, have been reported in schizophrenia. Recently, there have been conflicting reports that the increase in plasma cortisol or prolactin concentrations induced by meta-chlorophenylpiperazine (mCPP) was significantly blunted in schizophrenic patients compared with normal volunteers. Studies of the behavioral effects of mCPP, a serotonin (5-HT) receptor partial agonist with high affinity for 5-HT1C binding sites, have also yielded conflicting results in schizophrenic patients. The purpose of this study was to examine plasma levels of prolactin and cortisol, body temperature, and behavioral responses to mCPP and placebo in a single-blind study in 25 schizophrenic and 15 normal men. No differences either between schizophrenic patients and normal volunteers or between paranoid and undifferentiated/residual subtypes of schizophrenia were found in mCPP-induced prolactin, cortisol, or temperature responses. Schizophrenic patients and normal volunteers reported significant increases in feeling calm and feeling strange of comparable magnitude following mCPP. No significant differences between normal volunteers and schizophrenic patients were found in post-mCPP behavioral ratings, such as anxiety, irritability, depression, restlessness, or arousal.
精神分裂症患者中枢血清素能系统存在功能改变，包括突触前和突触后功能。最近，有相互矛盾的报道称，与正常志愿者相比，间氯苯哌嗪（mCPP）诱导的精神分裂症患者血浆皮质醇或催乳素浓度升高明显减弱。对mCPP（一种对5-HT1C结合位点具有高亲和力的血清素（5-HT）受体部分激动剂）行为效应的研究在精神分裂症患者中也得出了相互矛盾的结果。本研究的目的是在一项单盲研究中，检测25名精神分裂症男性和15名正常男性的血浆催乳素和皮质醇水平、体温以及对mCPP和安慰剂的行为反应。在mCPP诱导的催乳素、皮质醇或体温反应方面，未发现精神分裂症患者与正常志愿者之间或偏执型与未分化/残留型精神分裂症亚型之间存在差异。精神分裂症患者和正常志愿者报告称，服用mCPP后，感到平静和感到奇怪的程度有显著增加。在mCPP后的行为评分（如焦虑、易怒、抑郁、不安或觉醒）方面，未发现正常志愿者与精神分裂症患者之间存在显著差异。
