Sabbe B, Hulstijn W, Maes M, Pier M, Scharpé S, Zitman F
Department of Psychiatry, University of Nijmegen, Reinier Postlaan 10, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Psychiatry Res. 2001 Dec 31;105(3):151-63. doi: 10.1016/s0165-1781(01)00326-2.
The mixed 5-HT receptor agonist/antagonist meta-chlorophenylpiperazine (mCPP) is known to suppress locomotor activity in mice and rats. This study aimed: (1) to determine whether mCPP induces cognitive and motor changes in normal human volunteers and how these changes relate to the neuroendocrine effects of mCPP; and (2) to compare these cognitive and motor changes to the known cognitive and motor slowing patterns in depression and schizophrenia. A computerized method (used in previous research) analyzed fine motor behavior during figure-copying tasks. In 14 normal male volunteers behavioral responses, body temperature, plasma levels of prolactin and cortisol, and cognitive and motor performance during figure-copying tasks were measured after a single oral dose of mCPP (0.5 mg/kg). mCPP-induced prolongation of the reaction times in all copying tasks, parallel to increases in cortisol and prolactin and some self-reported behavioral effects. There were no changes in the movement times or the velocities of the writing movements. In conclusion, mCPP induced cognitive, but not motor slowing, in normal male volunteers. This indicates that the human serotonin system is also implicated in psychomotor behavior. This pattern of slowing was different from that in depressed and schizophrenic patients.
混合性5-羟色胺（5-HT）受体激动剂/拮抗剂间氯苯哌嗪（mCPP）已知可抑制小鼠和大鼠的运动活性。本研究旨在：（1）确定mCPP是否会在正常人类志愿者中引起认知和运动变化，以及这些变化如何与mCPP的神经内分泌效应相关；（2）将这些认知和运动变化与抑郁症和精神分裂症中已知的认知和运动迟缓模式进行比较。一种计算机化方法（用于先前的研究）分析了图形复制任务期间的精细运动行为。在14名正常男性志愿者中，单次口服mCPP（0.5mg/kg）后，测量了行为反应、体温、催乳素和皮质醇的血浆水平以及图形复制任务期间的认知和运动表现。mCPP导致所有复制任务中的反应时间延长，同时皮质醇和催乳素增加以及一些自我报告的行为效应。书写动作的移动时间或速度没有变化。总之，mCPP在正常男性志愿者中引起认知减慢，但未引起运动减慢。这表明人类5-羟色胺系统也与精神运动行为有关。这种减慢模式与抑郁症和精神分裂症患者不同。
