Antkiewicz-Michaluk L, Romańska I, Vetulani J
Department of Biochemistry, Polish Academy of Sciences, Krakow, Poland.
Psychopharmacology (Berl). 1996 Nov;128(1):39-44. doi: 10.1007/s002130050107.
The effect of single and multiple administration of Ca2+ channel antagonists, nifedipine and verapamil, on concentrations of dopamine and its metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), was investigated in the mesolimbic (cortex, nucleus accumbens) and extrapyramidal (striatum) structures in Wistar rats. A single dose of nifedipine (10 mg/kg IP) produced some activation of the dopaminergic system in both cortex (increase in DOPAC) and n. accumbens (increase in HVA); verapamil (20 mg/kg IP) produced an increase in HVA in the cortex only. Chronic treatment with either Ca2+ channel antagonist produced more marked activation of dopamine metabolism in the cortex and nucleus accumbens. Those changes were most expressed 1 h after the last treatment, but lasted for at least 24 h. No changes in dopamine metabolism were observed in the striatum. The present data suggest that Ca2+ channel antagonists after chronic treatment specifically activate the dopaminergic system in limbic structures.
研究了钙通道拮抗剂硝苯地平和维拉帕米单次及多次给药对Wistar大鼠中脑边缘系统（皮层、伏隔核）和锥体外系（纹状体）结构中多巴胺及其代谢产物3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）浓度的影响。单次给予硝苯地平（10 mg/kg腹腔注射）可使皮层（DOPAC增加）和伏隔核（HVA增加）的多巴胺能系统出现一定程度的激活；维拉帕米（20 mg/kg腹腔注射）仅使皮层中的HVA增加。用任何一种钙通道拮抗剂进行慢性治疗均可使皮层和伏隔核中的多巴胺代谢出现更明显的激活。这些变化在最后一次治疗后1小时最为明显，但至少持续24小时。在纹状体中未观察到多巴胺代谢的变化。目前的数据表明，慢性治疗后钙通道拮抗剂可特异性激活边缘系统结构中的多巴胺能系统。
