Tanaka H, Taniguchi H, Mugitani T, Koishi Y, Masuyama M, Koyama H, Hoshima M, Takahashi T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Br J Surg. 1996 Oct;83(10):1444-7. doi: 10.1002/bjs.1800831038.
The ability of the angiogenesis inhibitor TNP-470 to prevent liver metastasis after partial hepatectomy, and whether TNP-470 impairs liver regeneration or skin wound healing, was evaluated. Following the injection of VX2 carcinoma cells into the portal vein of rabbits, half of the animals underwent resection of the middle hepatic lobe (hepatectomized group) and half did not (non-hepatectomized group). TNP-470 (50 mg) was infused continuously into the portal vein in both groups for 7 days, while controls received only water. The hepatectomized TNP-470-treated group had significantly fewer tumours (mean(s.e.m.) 23.3(12.3)) than the hepatectomized control group (123.7(24.4)). There was no significant difference in the 5-bromo-2'-deoxyuridine labelling index of regenerated hepatocytes between the TNP-470-treated and control groups. Wound healing in TNP-470-treated animals was not impaired. Intraportal infusion of TNP-470 prevents the recurrence of liver metastasis after partial hepatectomy without impairing healing or liver regeneration.
评估血管生成抑制剂TNP - 470预防部分肝切除术后肝转移的能力，以及TNP - 470是否会损害肝再生或皮肤伤口愈合。将VX2癌细胞注入兔门静脉后，一半动物接受肝中叶切除术（肝切除组），另一半不接受（非肝切除组）。两组均通过门静脉持续输注TNP - 470（50毫克），持续7天，而对照组仅接受水。接受TNP - 470治疗的肝切除组肿瘤数量（均值（标准误）为23.3（12.3））明显少于肝切除对照组（123.7（24.4））。TNP - 470治疗组与对照组再生肝细胞的5 - 溴 - 2'-脱氧尿苷标记指数无显著差异。TNP - 470治疗动物的伤口愈合未受损害。门静脉内输注TNP - 470可预防部分肝切除术后肝转移的复发，且不损害愈合或肝再生。
