Shi Ji-Hua, Line Pål-Dag
Ji-Hua Shi, Pål-Dag Line, Department of Transplantation Medicine, Institute for Surgical Research, Oslo University Hospital, Postboks 4950, Nydalen 0424, Oslo, Norway.
World J Gastroenterol. 2014 Nov 21;20(43):16167-77. doi: 10.3748/wjg.v20.i43.16167.
Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where activation and proliferation of mature hepatocytes, hepatic progenitor cells, non-parenchymal liver cells might favor both liver regeneration and tumor growth. This review highlights recent advances of tumor growth and development in the regenerating liver, possible mechanisms and clinical implications.
大手术后的肝脏再生可能会激活隐匿的微转移灶并促进肿瘤生长，导致肝肿瘤复发。肝脏再生过程中的分子变化可提供一种微环境，通过细胞信号通路的改变刺激肝内肿瘤增殖，在此过程中成熟肝细胞、肝祖细胞、非实质肝细胞的激活和增殖可能对肝脏再生和肿瘤生长均有利。本文综述了再生肝中肿瘤生长和发展的最新进展、可能的机制及临床意义。
