迷走神经刺激可增强右心室的收缩与舒张功能，并提高心率。

Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate.

作者信息

Henning R J, Feliciano L, Coers C M

机构信息

University of South Florida College of Medicine, Division of Cardiology, Tampa, FL, USA.

出版信息

Cardiovasc Res. 1996 Nov;32(5):846-53.

PMID:8944815

Abstract

OBJECTIVE

To determine the effects of vasoactive intestinal peptide, released from the right and left vagal nerves, on ventricular contraction, relaxation, and heart rate.

METHODS

The muscarinic and beta-adrenergic receptors were blocked with atropine and propranolol, and afterload was controlled in 48 anesthetized, open-chest mongrel dogs. Experiments were performed in the absence (Series 1, 10 dogs) and in the presence (Series 2, 22 dogs) of a controlled heart rate and prior to and after the administration of a sensitive and selective vasoactive intestinal peptide antagonist (Series 3, 16 dogs).

RESULTS

Right ventricular contraction (+dp/dtmax), relaxation (-dp/dtmin) and heart rate increased significantly during 20 Hz vagal nerve stimulation for 5 min. Vagal nerve stimulation in Series 1 increased right ventricular +dp/dtmax by 28% from a control value of 480 +/- 11 (P < 0.001) and right ventricular -dp/dtmin by 23% from a control value of 341 +/- 11 (P < 0.002). Left ventricular +dp/dtmax and -dp/dtmin increased slightly but not significantly. Vagal nerve stimulation also increased the heart rate by 29% from a control value of 149 +/- 2 (P < 0.001). During controlled heart rate in Series 2, vagal nerve stimulation at 20 Hz consistently increased right ventricular +dp/dtmax and -dp/dtmin comparable to Series 1 experiments but did not increase left ventricular +dp/dtmax or -dp/dtmin. Injection of the vasoactive intestinal peptide antagonist [4Cl-DPhe6, Leu17]VIP into the right coronary artery of 16 dogs in Series 3 did not affect right ventricular +dp/dtmax, -dp/dtmin, or heart rate. However, this antagonist substantially decreased the vagal-induced increases in right ventricular +dp/dtmax, -dp/dtmin, and heart rate by 85, 63, and 71% (P < 0.005), respectively.

CONCLUSION

The present experiments suggest that vagal nerve stimulation releases vasoactive intestinal peptide (VIP) or a "VIP-like substance' that significantly increases right ventricular contraction, relaxation, and heart rate.

摘要

目的

确定左右迷走神经释放的血管活性肠肽对心室收缩、舒张及心率的影响。

方法

用阿托品和普萘洛尔阻断毒蕈碱能和β-肾上腺素能受体，并对48只麻醉开胸杂种犬的后负荷进行控制。实验在无控制心率（系列1，10只犬）和有控制心率（系列2，22只犬）的情况下进行，且在给予敏感且选择性的血管活性肠肽拮抗剂之前和之后（系列3，16只犬）进行。

结果

在20Hz迷走神经刺激5分钟期间，右心室收缩（+dp/dtmax）、舒张（-dp/dtmin）和心率显著增加。系列1中的迷走神经刺激使右心室+dp/dtmax较480±11的对照值增加28%（P<0.001），右心室-dp/dtmin较341±11的对照值增加23%（P<0.002）。左心室+dp/dtmax和-dp/dtmin略有增加但不显著。迷走神经刺激还使心率较149±2的对照值增加29%（P<0.001）。在系列2的控制心率期间，20Hz的迷走神经刺激持续增加右心室+dp/dtmax和-dp/dtmin，与系列1实验相当，但未增加左心室+dp/dtmax或-dp/dtmin。向系列3中的16只犬的右冠状动脉注射血管活性肠肽拮抗剂[4Cl-DPhe6，Leu17]VIP，未影响右心室+dp/dtmax、-dp/dtmin或心率。然而，该拮抗剂分别使迷走神经诱导的右心室+dp/dtmax、-dp/dtmin和心率增加显著降低85%、63%和71%（P<0.005）。