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心律失常患者基于设备的自主神经调节:迷走神经刺激的作用

Device-based autonomic modulation in arrhythmia patients: the role of vagal nerve stimulation.

作者信息

Huang William A, Shivkumar Kalyanam, Vaseghi Marmar

机构信息

UCLA Cardiac Arrhythmia Center, University of California, 100 Medical Plaza, Suite 660, Los Angeles, CA, 90095, USA.

出版信息

Curr Treat Options Cardiovasc Med. 2015 May;17(5):379. doi: 10.1007/s11936-015-0379-9.

DOI:10.1007/s11936-015-0379-9
PMID:25894588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4662680/
Abstract

Vagal nerve stimulation (VNS) has shown promise as an adjunctive therapy for management of cardiac arrhythmias by targeting the cardiac parasympathetic nervous system. VNS has been evaluated in the setting of ischemia-driven ventricular arrhythmias and atrial arrhythmias, as well as a treatment option for heart failure. As better understanding of the complexities of the cardiac autonomic nervous system is obtained, vagal nerve stimulation will likely become a powerful tool in the current cardiovascular therapeutic armamentarium.

摘要

通过靶向心脏副交感神经系统,迷走神经刺激(VNS)已显示出作为治疗心律失常辅助疗法的潜力。VNS已在缺血驱动的室性心律失常和房性心律失常的背景下进行了评估,也是心力衰竭的一种治疗选择。随着对心脏自主神经系统复杂性的更深入了解,迷走神经刺激可能会成为当前心血管治疗手段中的一种有力工具。

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本文引用的文献

1
Low-level vagosympathetic trunk stimulation inhibits atrial fibrillation in a rabbit model of obstructive sleep apnea.低水平迷走交感干刺激可抑制阻塞性睡眠呼吸暂停兔模型中的心房颤动。
Heart Rhythm. 2015 Apr;12(4):818-24. doi: 10.1016/j.hrthm.2014.12.024. Epub 2014 Dec 19.
2
Effects of vagus nerve stimulation via cholinergic anti-inflammatory pathway activation on myocardial ischemia/reperfusion injury in canine.通过胆碱能抗炎途径激活迷走神经刺激对犬心肌缺血/再灌注损伤的影响
Int J Clin Exp Med. 2014 Sep 15;7(9):2615-23. eCollection 2014.
3
Autonomic regulation therapy via left or right cervical vagus nerve stimulation in patients with chronic heart failure: results of the ANTHEM-HF trial.慢性心力衰竭患者通过左或右颈迷走神经刺激进行自主神经调节治疗:ANTHEM-HF试验结果
J Card Fail. 2014 Nov;20(11):808-16. doi: 10.1016/j.cardfail.2014.08.009. Epub 2014 Sep 1.
4
Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial.慢性迷走神经刺激治疗低射血分数心力衰竭:心力衰竭神经心脏治疗(NECTAR-HF)随机对照试验的结果
Eur Heart J. 2015 Feb 14;36(7):425-33. doi: 10.1093/eurheartj/ehu345. Epub 2014 Aug 31.
5
Changes in the loading conditions induced by vagal stimulation modify the myocardial infarct size through sympathetic-parasympathetic interactions.迷走神经刺激引起的负荷条件变化通过交感 - 副交感神经相互作用改变心肌梗死面积。
Pflugers Arch. 2015 Jul;467(7):1509-1522. doi: 10.1007/s00424-014-1591-2. Epub 2014 Aug 17.
6
Vagus nerve stimulation initiated late during ischemia, but not reperfusion, exerts cardioprotection via amelioration of cardiac mitochondrial dysfunction.迷走神经刺激在缺血晚期而不是再灌注时启动,通过改善心脏线粒体功能障碍发挥心脏保护作用。
Heart Rhythm. 2014 Dec;11(12):2278-87. doi: 10.1016/j.hrthm.2014.08.001. Epub 2014 Aug 2.
7
Electrophysiological effects of right and left vagal nerve stimulation on the ventricular myocardium.右侧和左侧迷走神经刺激对心室心肌的电生理效应。
Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H722-31. doi: 10.1152/ajpheart.00279.2014. Epub 2014 Jul 11.
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Sympathetic nerve fibers in human cervical and thoracic vagus nerves.人类颈迷走神经和胸迷走神经中的交感神经纤维。
Heart Rhythm. 2014 Aug;11(8):1411-7. doi: 10.1016/j.hrthm.2014.04.032. Epub 2014 Apr 24.
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Role of the autonomic nervous system in modulating cardiac arrhythmias.自主神经系统在调节心律失常中的作用。
Circ Res. 2014 Mar 14;114(6):1004-21. doi: 10.1161/CIRCRESAHA.113.302549.
10
Vagal control of cardiac electrical activity and wall motion during ventricular fibrillation in large animals.在大型动物的心室颤动期间,迷走神经对心脏电活动和壁运动的控制。
Auton Neurosci. 2014 Jul;183:12-22. doi: 10.1016/j.autneu.2014.01.009. Epub 2014 Feb 2.