Slevin N J, Irwin C J, Banerjee S S, Gupta N K, Farrington W T
Department of Radiotherapy, Christie Hospital, Manchester, UK.
J Laryngol Otol. 1996 Nov;110(11):1012-6.
Olfactory neuroblastoma is an uncommon tumour arising in the nasal cavity or paranasal sinuses. We report the management of nine cases treated with external beam radiotherapy subsequent to surgery, either attempted definitive removal or biopsy only. Recent refinements in pathological evaluation of these tumours are discussed. Seven cases were deemed classical olfactory neuroblastoma whilst two were classified as neuroendocrine carcinoma. The clinical features, radiotherapy technique and variable natural history are presented. Seven of eight patients treated radically were controlled locally, with a minimum follow-up of two years. Three patients developed cervical lymph node disease and three patients died of systemic metastatic disease. Suggestions are made as to which patients should have en-bloc resection rather than definitive radiotherapy.
嗅神经母细胞瘤是一种发生于鼻腔或鼻窦的罕见肿瘤。我们报告了9例患者的治疗情况，这些患者在手术（无论是尝试根治性切除还是仅行活检）后接受了外照射放疗。文中讨论了这些肿瘤病理评估的最新进展。7例被认为是经典型嗅神经母细胞瘤，2例被归类为神经内分泌癌。介绍了其临床特征、放疗技术及不同的自然病程。8例接受根治性治疗的患者中有7例局部得到控制，最短随访时间为2年。3例患者出现颈部淋巴结病变，3例患者死于全身转移性疾病。针对哪些患者应行整块切除而非根治性放疗提出了建议。
