Kwan K H, Higuchi W I, Molokhia A M, Hofmann A F
J Pharm Sci. 1977 Aug;66(8):1094-101. doi: 10.1002/jps.2600660811.
A physical model approach was utilized to investigate cholesterol monohydrate dissolution kinetics in simulated bile. The static pellet method and the Berthoud theory were employed to assess the contributions of the diffusion-convection mass transfer resistance and those of the interfacial resistance to the overall kinetics. For almost all situations studied, the interfacial resistance was the dominant rate-determining factor. The effects of four bile acids and their concentrations, the bile acid-lecithin ratio, and the added electrolytes and their concentrations on the interfacial resistance were examined. The results were correlated with those obtained with human bile samples, and the indications were that the kinetics of cholesterol dissolution in bile may be explainable on the basis of the principal bile acids, lecithin, and the electrolytes in the bile.
采用物理模型方法研究了模拟胆汁中胆固醇一水合物的溶解动力学。运用静态颗粒法和贝托德理论评估扩散-对流传质阻力以及界面阻力对整体动力学的贡献。对于几乎所有研究的情况，界面阻力是主要的速率决定因素。研究了四种胆汁酸及其浓度、胆汁酸与卵磷脂的比例以及添加的电解质及其浓度对界面阻力的影响。将结果与用人胆汁样本获得的结果进行了关联，结果表明胆汁中胆固醇溶解的动力学可以基于胆汁中的主要胆汁酸、卵磷脂和电解质来解释。
