加速胆结石溶解
Accelerating gallstone dissolution.
作者信息
Tao J C, Cussler E L, Evans D F
出版信息
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3917-21. doi: 10.1073/pnas.71.10.3917.
Abstract
The dissolution rates of cholesterol in model bile salt solutions are controlled by diffusion in slowly flowing bile and by interfacial kinetics in rapidly flowing bile. At low flow, dissolution varies with the square root of bile flow and can be predicted, a priori, from existing correlations of mass transfer. At high bile flow, dissolution is independent of bile flow and is probably dominated by the rate of micelle adsorption. These results show that cholesterol gallstone dissolution, a potential nonsurgical therapy for cholelithiasis, can be accelerated little in slow bile, but more significantly in rapidly flowing bile.
摘要
胆固醇在模拟胆盐溶液中的溶解速率，在缓慢流动的胆汁中受扩散控制，在快速流动的胆汁中受界面动力学控制。在低流速时，溶解速率随胆汁流速的平方根变化，并且可以根据现有的传质相关性事先预测。在高胆汁流速时，溶解与胆汁流速无关，可能受胶束吸附速率主导。这些结果表明，胆固醇胆结石溶解作为一种潜在的胆结石非手术治疗方法，在缓慢流动的胆汁中加速效果甚微，但在快速流动的胆汁中加速效果更显著。
相似文献
1
Accelerating gallstone dissolution.加速胆结石溶解
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3917-21. doi: 10.1073/pnas.71.10.3917.
2
Dissolution rate studies of cholesterol monohydrate in bile acid-lecithin solutions using the rotatingdisk method.使用旋转圆盘法对胆固醇一水合物在胆汁酸 - 卵磷脂溶液中的溶解速率进行研究。
J Pharm Sci. 1976 May;65(5):685-9. doi: 10.1002/jps.2600650514.
3
Participation of micelle at crystal-solution interface in rate-determining step for cholesterol gallstone dissolution in unsaturated bile media.在不饱和胆汁介质中胆固醇胆结石溶解的速率决定步骤中，胶束在晶体 - 溶液界面的参与情况。
J Pharm Sci. 1973 Apr;62(4):695-6. doi: 10.1002/jps.2600620440.
4
Evaluation of lincomycin as a cholesterol gallstone dissolution rate accelerator.林可霉素作为胆固醇性胆结石溶解速率促进剂的评估
J Pharm Sci. 1985 Jun;74(6):621-4. doi: 10.1002/jps.2600740608.
5
Dissolution kinetics of cholesterol in simulated bile I: Influence of bile acid type and concentration, bile acid-lecithin ration, and added electrolyte.胆固醇在模拟胆汁中的溶解动力学I：胆汁酸类型与浓度、胆汁酸-卵磷脂比例及添加电解质的影响
J Pharm Sci. 1977 Aug;66(8):1094-101. doi: 10.1002/jps.2600660811.
6
Dissolution kinetics of cholesterol in simulated bile II: influence of simulated bile composition.胆固醇在模拟胆汁中的溶解动力学II：模拟胆汁成分的影响
J Pharm Sci. 1978 Dec;67(12):1711-4. doi: 10.1002/jps.2600671220.
7
Diffusion in bile and its implications on detergency.胆汁中的扩散及其对去污力的影响。
Biochim Biophys Acta. 1975 Jun 23;388(3):385-96. doi: 10.1016/0005-2760(75)90097-1.
8
The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man.胆固醇在胆汁中溶解性的物理化学性质。与人类胆结石形成及溶解的关系。
J Clin Invest. 1978 Apr;61(4):998-1026. doi: 10.1172/JCI109025.
9
Effects of hydrophobic and hydrophilic bile salts on gallstone growth and dissolution in model biles.疏水性和亲水性胆盐对模型胆汁中胆结石生长和溶解的影响。
Biochim Biophys Acta. 2005 Jan 5;1686(3):209-19. doi: 10.1016/j.bbalip.2004.10.004.
10
Dissolution rates of cholesterol monohydrate crystals and human cholesterol gallstones in bile acid-lecithin solutions: enhancing effect of added alkyl quaternary ammonium salts.胆固醇单水合物晶体和人胆固醇胆结石在胆汁酸 - 卵磷脂溶液中的溶解速率：添加烷基季铵盐的增强作用
J Pharm Sci. 1973 Jul;62(7):1207-8. doi: 10.1002/jps.2600620737.
引用本文的文献
1
The relative importance of internal and external physical resistances to mass transfer for caffeine release from apple pectin tablets.内部和外部物理传质阻力对苹果果胶片中咖啡因释放的相对重要性。
Curr Res Food Sci. 2022 Mar 26;5:634-641. doi: 10.1016/j.crfs.2022.03.014. eCollection 2022.
2
Formation of cholesterol crystals at a mucin coated substrate.在粘蛋白包被的底物上形成胆固醇晶体。
Pharm Res. 2006 Oct;23(10):2413-6. doi: 10.1007/s11095-006-9004-7. Epub 2006 Aug 23.
3
Comparison of the mechanism of dissolution of hydrocortisone in simple and mixed micelle systems.氢化可的松在单胶束体系和混合胶束体系中溶解机制的比较。
Pharm Res. 1993 Jun;10(6):865-70. doi: 10.1023/a:1018961227717.
4
Gallstone dissolution with chenodeoxycholic acid. A clinical study.鹅去氧胆酸溶解胆结石。一项临床研究。
Klin Wochenschr. 1980 Mar 17;58(6):313-20. doi: 10.1007/BF01476574.
5
Solubilization and wetting effects of bile salts on the dissolution of steroids.胆汁盐对类固醇溶解的增溶和湿润作用。
Pharm Res. 1991 Dec;8(12):1461-9. doi: 10.1023/a:1015877929381.
6
The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man.胆固醇在胆汁中溶解性的物理化学性质。与人类胆结石形成及溶解的关系。
J Clin Invest. 1978 Apr;61(4):998-1026. doi: 10.1172/JCI109025.
7
Cholesterol monohydrate growth in model bile solutions.模型胆汁溶液中胆固醇一水合物的生长
Proc Natl Acad Sci U S A. 1978 Dec;75(12):6230-4. doi: 10.1073/pnas.75.12.6230.
本文引用的文献
1
The biophysics of lipidic associations. I. The ternary systems: lecithin-bile salt-water.脂质缔合的生物物理学。I. 三元体系：卵磷脂-胆汁盐-水。
Biochim Biophys Acta. 1966 Dec 7;125(3):563-80.
2
Dissolution rates in surfactant solutions under stirred and static conditions.搅拌和静态条件下表面活性剂溶液中的溶解速率。
J Pharm Sci. 1968 May;57(5):787-91. doi: 10.1002/jps.2600570513.
3
Cholesterol dissolution rate in micellar bile acid solutions: retarding effect of added lecithin.胆固醇在胶束胆汁酸溶液中的溶解速率：添加卵磷脂的阻滞作用。
Science. 1972 Nov 10;178(4061):633-4. doi: 10.1126/science.178.4061.633.
4
Dissolution of cholesterol gallstones by chenodeoxycholic acid.鹅去氧胆酸对胆固醇胆结石的溶解作用。
N Engl J Med. 1972 Jan 6;286(1):1-8. doi: 10.1056/NEJM197201062860101.
5
The formation of gallstones.胆结石的形成。
Adv Intern Med. 1970;16:243-64.
6
Theoretical model studies of intestinal drug absorption. IV. Bile acid transport at premicellar concentrations across diffusion layer-membrane barrier.肠道药物吸收的理论模型研究。IV. 前胶束浓度下胆汁酸跨扩散层-膜屏障的转运
J Pharm Sci. 1974 May;63(5):686-90. doi: 10.1002/jps.2600630508.
7
8
Dissolution rates of cholesterol monohydrate crystals and human cholesterol gallstones in bile acid-lecithin solutions: enhancing effect of added alkyl quaternary ammonium salts.胆固醇单水合物晶体和人胆固醇胆结石在胆汁酸 - 卵磷脂溶液中的溶解速率：添加烷基季铵盐的增强作用
J Pharm Sci. 1973 Jul;62(7):1207-8. doi: 10.1002/jps.2600620737.
9
Gallstone dissolution in man using chenodeoxycholic acid.使用鹅去氧胆酸溶解人体胆结石。
Lancet. 1972 Dec 9;2(7789):1213-6. doi: 10.1016/s0140-6736(72)92266-0.
Zotero 插件