Funakubo A, Higami T, Sakuma I, Fukui Y, Kawamura T, Sato K, Sueoka A, Nosé Y
Polytechnic University, Kanagawa, Japan.
ASAIO J. 1996 Sep-Oct;42(5):M837-40. doi: 10.1097/00002480-199609000-00108.
One of the limitations of conventional silicone hollow fiber oxygenators compared with microporous membrane oxygenators is poor gas permeability. However, the silicone hollow fiber is free from plasma leakage, which is the major life limiting factor of the microporous membrane oxygenator. It has been difficult to fabricate a fine, thin hollow fiber for reduction of resistance to gas permeability because of the poor mechanical strength of conventional silicone materials. The authors developed a novel silicone material with sufficient mechanical strength, and a fine silicone hollow fiber with a diameter of 30 microns and wall thickness of 50 microns, which is approximately half that of a conventional silicone hollow fiber. Using this newly developed silicone hollow fiber, the authors developed a compact extracapillary flow membrane oxygenator. The oxygenator consists of fine silicone hollow fibers inserted in a housing made of polycarbonate. The housing is a cylindrical case, 20 cm long and 55 mm in inside diameter. The hollow fibers are cross-wound. The surface area of the membrane is 2.0 m2, and priming volume is 230 ml. Gas transfer performance of the newly developed oxygenator was evaluated by in vitro experiments. Oxygen and carbon dioxide transfer rates were 195 ml/min and 165 ml/min, at a blood flow rate 3 L/min. The novel silicone membrane oxygenator developed in this study can be used for extended duration in such applications as extracorporeal membrane oxygenation.
与微孔膜氧合器相比，传统硅胶中空纤维氧合器的局限性之一是气体渗透性较差。然而，硅胶中空纤维不存在血浆渗漏问题，而血浆渗漏是微孔膜氧合器的主要寿命限制因素。由于传统硅胶材料的机械强度较差，很难制造出纤细的中空纤维以降低气体渗透阻力。作者开发了一种具有足够机械强度的新型硅胶材料，并制造出了直径为30微米、壁厚为50微米的精细硅胶中空纤维，其壁厚约为传统硅胶中空纤维的一半。利用这种新开发的硅胶中空纤维，作者开发了一种紧凑型毛细血管外流动膜氧合器。该氧合器由插入聚碳酸酯外壳中的精细硅胶中空纤维组成。外壳是一个圆柱形的盒子，长20厘米，内径55毫米。中空纤维交叉缠绕。膜的表面积为2.0平方米，预充量为230毫升。通过体外实验评估了新开发的氧合器的气体传输性能。在血流速度为3升/分钟时，氧气和二氧化碳的传输速率分别为195毫升/分钟和165毫升/分钟。本研究中开发的新型硅胶膜氧合器可用于体外膜肺氧合等需要较长时间使用的应用中。
