Wiselka M J, Read R, Finch R G
Department of Infectious Diseases and Tropical Medicine, Leicester Royal Infirmary, U.K.
J Infect. 1996 Nov;33(3):227-9. doi: 10.1016/s0163-4453(96)92393-2.
We present a patient with AIDS and toxoplasma encephalitis who was unable to tolerate established therapy with sulphadiazine or clindamycin but responded to oral azithromycin and pyrimethamine. The patient was maintained on oral azithromycin but subsequently relapsed after 8 months. The recurrence was successfully treated with intravenous azithromycin. The case illustrates that azithromycin can be used to treat patients with toxoplasma encephalitis who are unable to tolerate or fail to respond to other therapeutic agents. Failure of oral azithromycin may be due to inadequate tissue concentrations and patients may further benefit from intravenous administration.
我们报告了一名患有艾滋病和弓形虫脑炎的患者，该患者无法耐受已有的磺胺嘧啶或克林霉素治疗，但对口服阿奇霉素和乙胺嘧啶有反应。患者持续口服阿奇霉素治疗，但8个月后病情复发。复发后通过静脉注射阿奇霉素成功治愈。该病例表明，阿奇霉素可用于治疗无法耐受或对其他治疗药物无反应的弓形虫脑炎患者。口服阿奇霉素治疗失败可能是由于组织浓度不足，静脉给药可能使患者进一步获益。
