Torasdotter M, Metsis M, Henriksson B G, Winblad B, Mohammed A H
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge University Hospital, Sweden.
Neurosci Lett. 1996 Nov 1;218(2):107-10. doi: 10.1016/s0304-3940(96)13127-x.
Environmental enrichment results in structural changes in the brain. Recent findings indicate involvement of neurotrophins in neuronal plasticity. This study examined the effect of environmental complexity on the levels of neurotrophin-3 (NT-3) mRNA in the rat visual cortex and hippocampus, studied by in situ hybridization. Rats housed in groups in a complex, stimulating environment had significantly higher levels of NT-3 mRNA in the visual cortex and the hippocampus than rats housed in individual cages without stimulating objects. These results indicate a possible role for NT-3 in synaptic plasticity.
环境丰富化会导致大脑结构发生变化。最近的研究结果表明神经营养因子参与了神经元可塑性。本研究通过原位杂交技术，检测了环境复杂性对大鼠视觉皮层和海马体中神经营养因子-3（NT-3）mRNA水平的影响。与单独饲养在没有刺激物体的笼子里的大鼠相比，饲养在复杂、刺激环境中的大鼠组，其视觉皮层和海马体中的NT-3 mRNA水平显著更高。这些结果表明NT-3在突触可塑性中可能发挥作用。
