Kirby R F, Page W V, Johnson A K, Robillard J E
Department of Psychology, University of Iowa, Iowa City 52242, USA.
Am J Physiol. 1996 Nov;271(5 Pt 2):R1439-46. doi: 10.1152/ajpregu.1996.271.5.R1439.
The influence of altered dietary sodium on angiotensinogen and renin gene expression was examined in young normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Artificial rearing was used to increase or decrease dietary sodium intake during the preweanling period. In normally reared control animals, renal renin and liver angiotensinogen mRNA decreased between 6 and 30 postnatal days of age. In contrast, in the central nervous system, angiotensinogen mRNA increased between 6 and 30 days of age, and renin mRNA remained stable. Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Liver angiotensinogen mRNA decreased for animals on either diet on PD12 and PD18. Brain angiotensinogen and renin mRNA were not affected by dietary sodium levels. There were no strain-related differences in the response to high and low dietary sodium. These results demonstrate that 1) the peripheral and central renin-angiotensin systems do not have a common ontogenetic pattern of development, 2) they are independently regulated in response to dietary sodium variations, and 3) young WKY and SHR share very similar ontogenetic patterns of angiotensinogen and renin gene expression.
在年轻的血压正常的Wistar-Kyoto（WKY）大鼠和自发性高血压大鼠（SHR）中，研究了改变饮食中的钠对血管紧张素原和肾素基因表达的影响。在断奶前期，采用人工饲养的方法来增加或减少饮食中的钠摄入量。在正常饲养的对照动物中，出生后6至30天，肾肾素和肝脏血管紧张素原mRNA减少。相反，在中枢神经系统中，血管紧张素原mRNA在6至30天之间增加，而肾素mRNA保持稳定。出生后第6天（PD）至18天之间的饮食钠操纵显著影响肾肾素基因表达，低钠饮食使PD12和PD18时的肾素mRNA增加，高钠饮食使PD18时的肾素mRNA减少。PD12和PD18时，两种饮食的动物肝脏血管紧张素原mRNA均减少。脑内血管紧张素原和肾素mRNA不受饮食钠水平的影响。对高钠和低钠饮食的反应没有品系相关差异。这些结果表明：1）外周和中枢肾素-血管紧张素系统没有共同的个体发育模式；2）它们对饮食钠变化的反应是独立调节的；3）年轻的WKY大鼠和SHR大鼠在血管紧张素原和肾素基因表达的个体发育模式上非常相似。
