转染的溶组织内阿米巴过表达P-糖蛋白基因1可赋予其对吐根碱的抗性。 - Suppr

Suppr

超能文献

Overexpression of P-glycoprotein gene 1 by transfected Entamoeba histolytica confers emetine-resistance.

作者信息

Ghosh S K, Lohia A, Kumar A, Samuelson J

机构信息

Department of Tropical Public Health, Harvard School of Public Health, Boston, MA 02115, USA.

出版信息

Mol Biochem Parasitol. 1996 Nov 25;82(2):257-60. doi: 10.1016/0166-6851(96)02733-8.

DOI:10.1016/0166-6851(96)02733-8

PMID:8946391

Abstract

摘要

相似文献

Overexpression of P-glycoprotein gene 1 by transfected Entamoeba histolytica confers emetine-resistance.转染的溶组织内阿米巴过表达P-糖蛋白基因1可赋予其对吐根碱的抗性。

Mol Biochem Parasitol. 1996 Nov 25;82(2):257-60. doi: 10.1016/0166-6851(96)02733-8.

Expression and immunodetection of a P-glycoprotein in emetine-resistant trophozoites of Entamoeba histolytica.溶组织内阿米巴吐根碱抗性滋养体中P-糖蛋白的表达及免疫检测

Arch Med Res. 2000 Jul-Aug;31(4 Suppl):S288-90. doi: 10.1016/s0188-4409(00)00195-8.

Increase in mRNA of multiple Eh pgp genes encoding P-glycoprotein homologues in emetine-resistant Entamoeba histolytica parasites.

Gene. 1995 Oct 16;164(1):179-84. doi: 10.1016/0378-1119(95)00533-c.

Entamoeba histolytica EhPgp5 transcriptional activation depends on putative emetine response elements.溶组织内阿米巴EhPgp5转录激活依赖于假定的吐根碱反应元件。

Exp Parasitol. 2005 Jul;110(3):233-7. doi: 10.1016/j.exppara.2005.03.016.

Putative amplification of the EhPgp genes in Entamoeba histolytica emetine-resistant mutants.溶组织内阿米巴耐吐根碱突变体中EhPgp基因的假定扩增。

Arch Med Res. 1997;28 Spec No:66-8.

Isolation of emetine resistant clones of Entamoeba histolytica by petri dish agar method.

Indian J Med Res. 2000 Jan;111:11-3.

A Novel Heat Shock Element (HSE) in that Regulates the Transcriptional Activation of the Gene in the Presence of Emetine Drug.一种新型热休克元件 (HSE) 在依米丁药物存在的情况下调节基因的转录激活。

Front Cell Infect Microbiol. 2017 Nov 29;7:492. doi: 10.3389/fcimb.2017.00492. eCollection 2017.

EhPgp5 mRNA stability is a regulatory event in the Entamoeba histolytica multidrug resistance phenotype.EhPgp5信使核糖核酸稳定性是溶组织内阿米巴多药耐药表型中的一种调控事件。

J Biol Chem. 2003 Mar 28;278(13):11273-80. doi: 10.1074/jbc.M211757200. Epub 2003 Jan 28.

Cis-elements upregulate the activity of the Entamoeba histolytica EhPgp1 gene promoter.顺式元件上调溶组织内阿米巴EhPgp1基因启动子的活性。

Arch Med Res. 2000 Jul-Aug;31(4 Suppl):S275-6. doi: 10.1016/s0188-4409(00)00201-0.

[Changes of E. histolytica from culture under the influence of emetine and fumagillin].[在吐根碱和烟曲霉素影响下培养的溶组织内阿米巴的变化]

Med Parazitol (Mosk). 1967 Mar-Apr;36(2):209-15.

引用本文的文献

Different Aspects of Emetine's Capabilities as a Highly Potent SARS-CoV-2 Inhibitor against COVID-19.吐根碱作为一种高效的抗新冠病毒SARS-CoV-2抑制剂的多方面能力

ACS Pharmacol Transl Sci. 2022 May 23;5(6):387-399. doi: 10.1021/acsptsci.2c00045. eCollection 2022 Jun 10.

Dissecting the Transcriptomes of Multiple Metronidazole-Resistant and Sensitive Strains Identified Distinct Genes and Pathways Associated with Drug Resistance and Cell Death.剖析多个甲硝唑耐药和敏感菌株的转录组，鉴定出与耐药性和细胞死亡相关的不同基因和通路。

Biomedicines. 2021 Dec 2;9(12):1817. doi: 10.3390/biomedicines9121817.

The Jacob2 lectin of the Entamoeba histolytica cyst wall binds chitin and is polymorphic.溶组织内阿米巴包囊壁的 Jacob2 凝集素结合几丁质，且具有多态性。

PLoS Negl Trop Dis. 2010 Jul 20;4(7):e750. doi: 10.1371/journal.pntd.0000750.

P-glycoprotein structure and evolutionary homologies.P-糖蛋白结构与进化同源性。

Cytotechnology. 1998 Sep;27(1-3):1-30. doi: 10.1023/A:1008080911522.

Identification of an Entamoeba histolytica serine-, threonine-, and isoleucine-rich protein with roles in adhesion and cytotoxicity.鉴定一种在黏附和细胞毒性中起作用的富含丝氨酸、苏氨酸和异亮氨酸的溶组织内阿米巴蛋白。

Eukaryot Cell. 2007 Nov;6(11):2139-46. doi: 10.1128/EC.00174-07. Epub 2007 Sep 7.

Why metronidazole is active against both bacteria and parasites.为什么甲硝唑对细菌和寄生虫都有活性。

Antimicrob Agents Chemother. 1999 Jul;43(7):1533-41. doi: 10.1128/AAC.43.7.1533.

Chitinase secretion by encysting Entamoeba invadens and transfected Entamoeba histolytica trophozoites: localization of secretory vesicles, endoplasmic reticulum, and Golgi apparatus.侵袭内阿米巴包囊化过程及转染的溶组织内阿米巴滋养体的几丁质酶分泌：分泌囊泡、内质网和高尔基体的定位

Infect Immun. 1999 Jun;67(6):3073-81. doi: 10.1128/IAI.67.6.3073-3081.1999.

Hsp60 is targeted to a cryptic mitochondrion-derived organelle ("crypton") in the microaerophilic protozoan parasite Entamoeba histolytica.热休克蛋白60定位于微需氧原生动物寄生虫溶组织内阿米巴的一种隐匿的线粒体衍生细胞器（“隐粒体”）中。

Mol Cell Biol. 1999 Mar;19(3):2198-205. doi: 10.1128/MCB.19.3.2198.

Involvement of p21racA, phosphoinositide 3-kinase, and vacuolar ATPase in phagocytosis of bacteria and erythrocytes by Entamoeba histolytica: suggestive evidence for coincidental evolution of amebic invasiveness.p21racA、磷酸肌醇3激酶和液泡ATP酶在溶组织内阿米巴对细菌和红细胞的吞噬作用中的参与：阿米巴侵袭性巧合进化的提示性证据。

Infect Immun. 1997 Oct;65(10):4243-9. doi: 10.1128/iai.65.10.4243-4249.1997.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验