Steele R J, Dermon C R, Stewart M G
Brain and Behaviour Research Group, Open University, Milton Keynes, United Kingdom.
Neurobiol Learn Mem. 1996 Sep;66(2):236-40. doi: 10.1006/nlme.1996.0064.
The N-methyl-D-aspartate (NMDA) receptor plays an important role in acquisition of memory after one-trial passive avoidance training in day-old chicks. Here, we examined the effect of D-cycloserine, a partial agonist of the glycine site on the NMDA receptor, on memory retention after training on weak aversive stimuli (10% methyl anthranilate). Bilateral, or unilateral, intracranial injections of 5 microliters of 600 mumol.l-1 D-cycloserine (DCS) were made into the intermediate and medial hyperstriatum ventrale 5 min posttraining and chicks were tested either 30 min or 1, 6, or 24 h later. Enhanced memory retention (number of chicks avoiding) occurred after bilateral, or left hemisphere, injections of DCS (compared to saline-injected controls), when chicks were tested at 1 and 6 h, but not at 30 min or 24 h posttraining. These data suggest that activation of the glycine site on the NMDA receptor in the immediate posttraining period can transiently extend the retention period of memory for a weak aversive stimulus.
N-甲基-D-天冬氨酸（NMDA）受体在雏鸡单次被动回避训练后的记忆形成中起着重要作用。在此，我们研究了NMDA受体甘氨酸位点的部分激动剂D-环丝氨酸对弱厌恶刺激（10%邻氨基苯甲酸甲酯）训练后记忆保持的影响。训练后5分钟，将5微升600微摩尔/升的D-环丝氨酸（DCS）双侧或单侧颅内注射到中腹侧纹状体中间部，雏鸡分别在30分钟或1、6或24小时后接受测试。当雏鸡在训练后1小时和6小时接受测试时，双侧或左半球注射DCS后（与注射生理盐水的对照组相比），记忆保持增强（避免的雏鸡数量），但在训练后30分钟或24小时时没有增强。这些数据表明，训练后即刻激活NMDA受体的甘氨酸位点可短暂延长对弱厌恶刺激的记忆保持期。
