Malik M
Department of Cardiological Sciences, St. George's Hospital Medical School, London, United Kingdom.
Pacing Clin Electrophysiol. 1996 Nov;19(11 Pt 1):1635-9. doi: 10.1111/j.1540-8159.1996.tb03191.x.
The original data of 109 pairs of RR and QT intervals published by Dr. Bazett in 1920 were subjected to a computerized optimization of the QT/RR relationship. Four generic formulae expressing QT interval as alpha + beta RR mu, alpha + beta e mu RR, alpha + beta e(1/mu RR), and alpha + beta ln mu(10 x RR) were used, and for each formula, optimum combinations parameters alpha, beta, and mu were established that lead to minimum differences between the actual QT interval intervals and values predicted by the model. The results show that independent of the generic formula used, parameters of the model can be selected that provide a close fit of the measured values. Compared to the optimum models obtained in this way, the optimum fit of the Bazett model, QT = beta RR1/2, overestimates the QT intervals for slow heart rates. In addition to demonstrating the procedure of obtaining an optimum QT/RR model for a given data set, the study suggests that critical understanding of the principal limitations of every QT/RR model is more important than its mathematical form.
巴泽特博士于1920年发表的109对RR和QT间期的原始数据被用于对QT/RR关系进行计算机优化。使用了四个通用公式将QT间期表示为α + βRRμ、α + βeμRR、α + βe(1/μRR)和α + βlnμ(10×RR)，并且对于每个公式，确定了最优组合参数α、β和μ，这些参数使得实际QT间期与模型预测值之间的差异最小。结果表明，无论使用何种通用公式，都可以选择能紧密拟合测量值的模型参数。与通过这种方式获得的最优模型相比，巴泽特模型QT = βRR1/2的最优拟合对于缓慢心率会高估QT间期。除了展示为给定数据集获得最优QT/RR模型的过程外，该研究还表明，对每个QT/RR模型主要局限性的批判性理解比其数学形式更为重要。
