Rahman M E, Ishikawa H, Watanabe Y, Endo A
Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Japan.
Reprod Toxicol. 1996 Nov-Dec;10(6):485-9. doi: 10.1016/s0890-6238(96)00135-9.
When pregnant mice were given small doses of teratogens (cytosine arabinoside, mitomycin C, or busulfan) that did not induce anomalies of any other organs, a high incidence of carpal and tarsal bone anomalies still occurred. The carpal and tarsal bones may be used as a sensitive target for teratogenicity testing.
当给怀孕小鼠小剂量的致畸剂（阿糖胞苷、丝裂霉素C或白消安），这些致畸剂不会诱发任何其他器官的异常时，腕骨和跗骨异常的发生率仍然很高。腕骨和跗骨可作为致畸性测试的敏感靶点。
