Rahman M E, Ishikawa H, Watanabe Y, Endo A
Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Japan.
Reprod Toxicol. 1995 May-Jun;9(3):289-96. doi: 10.1016/0890-6238(95)00011-x.
Pregnant mice were injected intraperitoneally with a single dose of 5 mg/kg of cytosine arabinoside (Ara-C) on different gestational days (dg 9-12). On the 15th postnatal day, skeletal anomalies of the paws were examined, and associations between carpal and tarsal bone anomalies and digit anomalies were assessed. The types of carpal and tarsal bone anomalies differed according to the time of exposure to Ara-C during pregnancy. It was also found that the "critical period" for the carpal and tarsal bones is wider than that of the digits. The occurrence of anomalies of phalangeal and metacarpal/metatarsal bones was always associated with carpal or tarsal bone anomalies, although some carpal and tarsal bone anomalies occurred alone. It may be that the Ara-C threshold is considerably lower in the carpal and tarsal bones than in the digits.
在不同的妊娠天数（妊娠第9 - 12天），给怀孕小鼠腹腔注射单剂量5毫克/千克的阿糖胞苷（Ara - C）。在出生后第15天，检查爪子的骨骼异常情况，并评估腕骨和跗骨异常与指骨异常之间的关联。腕骨和跗骨异常的类型因孕期接触阿糖胞苷的时间而异。还发现腕骨和跗骨的“关键期”比指骨的更宽。指骨和掌骨/跖骨异常的发生总是与腕骨或跗骨异常相关，尽管有些腕骨和跗骨异常是单独出现的。可能阿糖胞苷在腕骨和跗骨中的阈值比在指骨中要低得多。
