Ambinder R F, Robertson K D, Moore S M, Yang J
Johns Hopkins Oncology Center, Baltimore, MD 21231, USA.
Semin Cancer Biol. 1996 Aug;7(4):217-26. doi: 10.1006/scbi.1996.0029.
Conventional approaches to the treatment of malignancy are often not curative or are associated with serious complications. New approaches to treatment are needed. A variety of specific approaches to the destruction of virus-associated tumor cells are illustrated in the context of EBV-associated Hodgkin's disease and nasopharyngeal carcinoma. Viral antigens expressed by tumors may be targeted by cytotoxic T cells. Other viral antigens not naturally expressed by tumors may be induced by pharmacologic manipulations such as treatment with demethylating agents. Viral enzymes not naturally expressed by tumors such as thymidine kinase may be induced by protein kinase C activators, thus rendering tumor cells sensitive to killing by ganciclovir.
恶性肿瘤的传统治疗方法往往无法治愈，或会引发严重并发症。因此需要新的治疗方法。本文结合EB病毒相关的霍奇金淋巴瘤和鼻咽癌，阐述了多种针对病毒相关肿瘤细胞的特异性治疗方法。肿瘤表达的病毒抗原可被细胞毒性T细胞靶向作用。肿瘤未自然表达的其他病毒抗原可通过药物处理诱导产生，如使用去甲基化剂进行治疗。肿瘤未自然表达的病毒酶，如胸苷激酶，可由蛋白激酶C激活剂诱导产生，从而使肿瘤细胞对更昔洛韦杀伤敏感。
