Raab-Traub N
Department of Microbiology & Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295.
Infect Agents Dis. 1992 Aug;1(4):173-84.
Nasopharyngeal carcinoma develops with extremely high incidence in discrete populations and geographic locations. It is consistently associated with the ubiquitous Epstein-Barr herpesvirus (EBV). The structure of EBV DNA indicates that the tumor is a clonal proliferation that developed subsequent to EBV infection. Specific viral genes are consistently expressed within all cells of the tumor. This consistent expression may indicate that the viral gene products are required for tumor growth. Genetic or environmental factors may affect the expression of these critical viral genes or cellular genes and contribute to tumor progression.
鼻咽癌在特定人群和地理位置的发病率极高。它一直与普遍存在的爱泼斯坦-巴尔疱疹病毒（EBV）相关。EBV DNA的结构表明肿瘤是EBV感染后发生的克隆性增殖。特定的病毒基因在肿瘤的所有细胞中持续表达。这种持续表达可能表明病毒基因产物是肿瘤生长所必需的。遗传或环境因素可能影响这些关键病毒基因或细胞基因的表达，并促进肿瘤进展。
