Harpaz N, Talbot I C
Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA.
Semin Diagn Pathol. 1996 Nov;13(4):339-57.
The development of colorectal cancer is the most serious long-term problem faced by patients with extensive ulcerative colitis and Crohn's colitis, with an incidence 20-fold higher and an average age of onset 20 years younger than colorectal cancer in the general population. This report summarizes the epidemiology, pathology, and recent advances in the molecular pathogenesis of colorectal cancer in inflammatory bowel disease and of its acknowledged precursor, mucosal dysplasia. It also reviews the rationale behind the use of endoscopic surveillance for dysplasia as a means of reducing cancer mortality, as well as some of the issues involved in its effective implementation.
结直肠癌的发生是广泛性溃疡性结肠炎和克罗恩氏结肠炎患者面临的最严重的长期问题，其发病率比普通人群中的结直肠癌高20倍，平均发病年龄比普通人群中的结直肠癌年轻20岁。本报告总结了炎症性肠病中结直肠癌及其公认的前驱病变——黏膜发育异常的流行病学、病理学以及分子发病机制的最新进展。它还回顾了使用内镜监测发育异常作为降低癌症死亡率的手段背后的基本原理，以及有效实施该监测所涉及的一些问题。
