通过新型克隆速激肽肽受体的异源表达进行功能表征
Functional characterization by heterologous expression of a novel cloned tachykinin peptide receptor.
作者信息
Donaldson L F, Haskell C A, Hanley M R
机构信息
Department of Biological Chemistry, University of California at Davis Medical School 95616, USA.
出版信息
Biochem J. 1996 Nov 15;320 ( Pt 1)(Pt 1):1-5. doi: 10.1042/bj3200001.
Abstract
An orphan receptor resembling the neurokinin 3 tachykinin receptor (NK3), initially claimed to be an atypical opioid receptor, is shown herein to respond potently to the physiological NK3 receptor ligand, neurokinin B. This 'NK4' receptor did not give functional responses in Xenopus oocytes to opioid agonists. However, NK4 receptor activation was inhibited by nanomolar concentrations of dynorphin. The NK4 receptor is therefore a tachykinin receptor which is functionally antagonized by an endogenous opioid peptide.
摘要
一种类似于神经激肽3速激肽受体（NK3）的孤儿受体，最初被认为是一种非典型阿片受体，本文显示它对生理性NK3受体配体神经激肽B有强烈反应。这种“NK4”受体在非洲爪蟾卵母细胞中对阿片类激动剂没有功能性反应。然而，纳摩尔浓度的强啡肽可抑制NK4受体的激活。因此，NK4受体是一种速激肽受体，可被内源性阿片肽进行功能拮抗。
相似文献
1
Functional characterization by heterologous expression of a novel cloned tachykinin peptide receptor.通过新型克隆速激肽肽受体的异源表达进行功能表征
Biochem J. 1996 Nov 15;320 ( Pt 1)(Pt 1):1-5. doi: 10.1042/bj3200001.
2
Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse.神经激肽 B 通过雄性小鼠中的多种速激肽受体激活弓状核 kisspeptin 神经元。
Endocrinology. 2013 Aug;154(8):2750-60. doi: 10.1210/en.2013-1231. Epub 2013 Jun 6.
3
Messenger RNA localization and further characterisation of the putative tachykinin receptor NK4 (NK3B).
Recept Channels. 2001;7(4):259-72.
4
A novel tachykinin-related peptide receptor. Sequence, genomic organization, and functional analysis.一种新型速激肽相关肽受体。序列、基因组结构及功能分析。
Eur J Biochem. 2002 Sep;269(17):4238-46. doi: 10.1046/j.1432-1033.2002.03106.x.
5
The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal.人速激肽NK1（短型）和速激肽NK4受体：重新评估
Eur J Pharmacol. 2002 Feb 15;437(1-2):27-30. doi: 10.1016/s0014-2999(02)01278-5.
6
Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor.
FEBS Lett. 1998 Nov 13;439(1-2):35-40. doi: 10.1016/s0014-5793(98)01331-3.
7
Identification of dynorphins as endogenous ligands for an opioid receptor-like orphan receptor.
J Biol Chem. 1995 Sep 29;270(39):22772-6. doi: 10.1074/jbc.270.39.22772.
8
In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics.两种非肽类速激肽 NK3 受体拮抗剂的体外和体内比较：通过增强脑穿透或改变药理学特性来提高疗效。
Eur J Pharmacol. 2010 Feb 10;627(1-3):106-14. doi: 10.1016/j.ejphar.2009.10.054. Epub 2009 Oct 30.
9
A role for tachykinins in female mouse and rat reproductive function.速激肽在雌性小鼠和大鼠生殖功能中的作用。
Biol Reprod. 2003 Sep;69(3):940-6. doi: 10.1095/biolreprod.103.017111. Epub 2003 May 28.
10
Functional couplings of the delta- and the kappa-opioid receptors with the G-protein-activated K+ channel.δ-阿片受体和κ-阿片受体与G蛋白激活的钾通道的功能偶联。
Biochem Biophys Res Commun. 1995 Mar 8;208(1):302-8. doi: 10.1006/bbrc.1995.1338.
引用本文的文献
1
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.《2013/14药理学简明指南：G蛋白偶联受体》
Br J Pharmacol. 2013 Dec;170(8):1459-581. doi: 10.1111/bph.12445.
2
The role of substance P in depression: therapeutic implications.P物质在抑郁症中的作用：治疗意义。
Dialogues Clin Neurosci. 2002 Mar;4(1):21-9. doi: 10.31887/DCNS.2002.4.1/mschwarz.
3
Neurokinin B and pre-eclampsia: a decade of discovery.神经激肽 B 与子痫前期：十年探索。
Reprod Biol Endocrinol. 2010 Jan 14;8:4. doi: 10.1186/1477-7827-8-4.
4
Substance P increases neutrophil adhesion to human umbilical vein endothelial cells.P物质增加中性粒细胞对人脐静脉内皮细胞的黏附。
Br J Pharmacol. 2003 Jul;139(6):1103-10. doi: 10.1038/sj.bjp.0705344.
5
Molecular and pharmacological characterization of a functional tachykinin NK3 receptor cloned from the rabbit iris sphincter muscle.从兔虹膜括约肌克隆的功能性速激肽NK3受体的分子和药理学特性
Br J Pharmacol. 1999 Oct;128(3):627-36. doi: 10.1038/sj.bjp.0702854.
本文引用的文献
1
Parathyroid hormone-related protein antagonizes the action of parathyroid hormone on adult cardiomyocytes.
J Biol Chem. 1996 Feb 9;271(6):3074-8. doi: 10.1074/jbc.271.6.3074.
2
The 'septide-sensitive' tachykinin receptor: still an enigma.“对速激肽敏感的”速激肽受体：仍是一个谜。
Trends Pharmacol Sci. 1995 Nov;16(11):365-7. doi: 10.1016/s0165-6147(00)89076-8.
3
PCR-direct sequencing of a GC-rich region by inclusion of 10% DMSO: application to mouse c-jun.通过加入10%二甲基亚砜对富含GC区域进行PCR直接测序：应用于小鼠c-jun基因
Biotechniques. 1993 Sep;15(3):372-4.
4
5
A chimeric study of the molecular basis of affinity and selectivity of the kappa and the delta opioid receptors. Potential role of extracellular domains.κ和δ阿片受体亲和力和选择性分子基础的嵌合研究。细胞外结构域的潜在作用。
J Biol Chem. 1995 May 26;270(21):12730-6. doi: 10.1074/jbc.270.21.12730.
6
Molecular biology and pharmacology of cloned opioid receptors.克隆化阿片受体的分子生物学与药理学
FASEB J. 1995 Apr;9(7):516-25. doi: 10.1096/fasebj.9.7.7737460.
7
The mammalian tachykinin receptors.哺乳动物速激肽受体。
Gen Pharmacol. 1995 Sep;26(5):911-44. doi: 10.1016/0306-3623(94)00292-u.
8
A new generation of Ca2+ indicators with greatly improved fluorescence properties.新一代具有大大改善的荧光特性的钙离子指示剂。
J Biol Chem. 1985 Mar 25;260(6):3440-50.
9
Cloning and expression of a rat neuromedin K receptor cDNA.大鼠神经介素K受体cDNA的克隆与表达
J Biol Chem. 1990 Jan 15;265(2):623-8.
10
Phylogeny of tachykinin receptor localization in the vertebrate central nervous system: apparent absence of neurokinin-2 and neurokinin-3 binding sites in the human brain.脊椎动物中枢神经系统中速激肽受体定位的系统发育：人脑中明显不存在神经激肽-2和神经激肽-3结合位点。
Brain Res. 1991 Jan 25;539(2):211-22. doi: 10.1016/0006-8993(91)91623-9.
Zotero 插件