Hakkak R, Korourian S, Ronis M J, Badger T M
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
Cancer Lett. 1996 Oct 22;107(2):257-64. doi: 10.1016/0304-3835(96)04379-0.
Epidemiological and animal studies have shown that diet and excessive alcohol consumption are major risk factors for liver and gastrointestinal cancers. This study investigated the effects of diet and alcohol consumption on azoxymethane (AOM)-induced liver and gastrointestinal neoplasia in male rats. Rats were infused intragastrically with control or ethanol-containing diets. After 35 days of dietary acclimatization, all rats received two intragastric infusions of AOM (15 mg/kg) separated by 1 week and then were maintained on standard rat food for 26 weeks. Results suggest that liver and duodenum are the major target organs when AOM is given orally and ethanol pre-exposure potentiates the AOM-induced hepatic and duodenal dysplasia.
流行病学和动物研究表明，饮食及过量饮酒是肝脏和胃肠道癌症的主要风险因素。本研究调查了饮食和饮酒对雄性大鼠中由氧化偶氮甲烷（AOM）诱导的肝脏和胃肠道肿瘤形成的影响。给大鼠经胃内灌注对照饮食或含乙醇饮食。在35天的饮食适应期后，所有大鼠接受两次间隔1周的胃内AOM灌注（15毫克/千克），然后给予标准大鼠食物并维持26周。结果表明，口服AOM时肝脏和十二指肠是主要靶器官，且预先接触乙醇会增强AOM诱导的肝脏和十二指肠发育异常。
