Modayur B R, Prothero J, Rosse C, Jakobovits R, Brinkley J F
Dept. Biological Structure, University of Washington, Seattle 98195, USA.
Proc AMIA Annu Fall Symp. 1996:304-8.
The Human Brain Project was initiated with the goal of developing methods for managing and sharing information about the brain. As a prototype Human Brain Project application we are developing a system for organizing, visualizing, integrating and sharing information about human language function. The goal of the brain mapping component of our work, described in this article, is to generate the 3D location and extent of cortical language sites with respect to a uniform, 3D patient coordinate system. The language sites of individual patients can then be combined with or related to other patient data in terms of a Talairach, surface-based, or other deformable coordinate systems. Language site mapping is done by visually comparing an intraoperative photograph with the rendered image (from MRI data). The techniques outlined in this article have been utilized to map cortical language sites of six patients. Preliminary results point to the adequacy of our volume visualizations for language mapping. The strength of the visualization scheme lies in the combination of interactive segmentation with volume and surface visualization. We are now in the process of acquiring more patient data to further validate the usefulness of our method.
人类大脑计划的启动目标是开发管理和共享大脑信息的方法。作为人类大脑计划的一个应用原型，我们正在开发一个用于组织、可视化、整合和共享人类语言功能信息的系统。本文所述工作的脑图谱部分的目标是，相对于一个统一的三维患者坐标系，生成皮质语言区的三维位置和范围。然后，个体患者的语言区可以与其他患者数据在Talairach坐标系、基于表面的坐标系或其他可变形坐标系方面进行合并或关联。语言区映射是通过将术中照片与渲染图像（来自MRI数据）进行视觉比较来完成的。本文概述的技术已被用于绘制六名患者的皮质语言区。初步结果表明我们的容积可视化对于语言映射是足够的。可视化方案的优势在于交互式分割与容积和表面可视化的结合。我们目前正在获取更多患者数据，以进一步验证我们方法的有效性。
