Friedman N L
Clinical Pharmacy Office, St. Joseph's Medical Center, South Bend, Indiana 46634-1935, USA.
Pharmacotherapy. 1996 Nov-Dec;16(6):986-95.
A MEDLINE search of the National Library of Medicine data base from 1966-1994 was performed to review the anatomy and pathophysiology of intractable hiccups and their nondrug and drug therapies. Pertinent articles were further reviewed for older references and related literature. The infrequent occurrence of intractable hiccups makes it difficult to perform large, well-controlled clinical trials. The only approved drug for the disorder, chlorpromazine, may not be acceptable for every patient. Studies have been conducted with metoclopramide, valproic acid, nifedipine, and baclofen as alternative therapies.
对美国国立医学图书馆数据库1966年至1994年期间的文献进行了医学文献分析联机检索（MEDLINE），以回顾顽固性呃逆的解剖学和病理生理学及其非药物和药物治疗方法。对相关文章进一步查阅以获取更早的参考文献和相关文献。顽固性呃逆的发生率较低，因此难以开展大规模、严格对照的临床试验。该疾病唯一获批的药物氯丙嗪并非对每个患者都适用。已开展了关于甲氧氯普胺、丙戊酸、硝苯地平和巴氯芬作为替代疗法的研究。
