McConkey D J, Orrenius S
Department of Cell Biology, University of Texas MD Anderson Cancer Center, Houston 77030, USA.
Stem Cells. 1996 Nov;14(6):619-31. doi: 10.1002/stem.140619.
Emerging evidence indicates that apoptosis is regulated by some of the same signal transduction pathways previously implicated in other physiological cellular responses, including alterations in intracellular Ca2+ compartmentalization, activation of protein kinases and phosphatases, alteratios in pH and oxidative stress. Interestingly, signals that promote apoptosis in one model can suppress cell death in another, indicating that cellular responses are determined by the intrinsic programming of the cell in question. This review will summarize current knowledge of the signal transduction pathways regulating apoptosis and discuss how they may be coupled to components of the molecular machinery for cell death.
新出现的证据表明，细胞凋亡是由一些先前涉及其他生理细胞反应的相同信号转导途径调控的，包括细胞内Ca2+ 分布的改变、蛋白激酶和磷酸酶的激活、pH值的变化以及氧化应激。有趣的是，在一种模型中促进细胞凋亡的信号在另一种模型中可能会抑制细胞死亡，这表明细胞反应是由所讨论细胞的内在程序决定的。本综述将总结目前关于调控细胞凋亡的信号转导途径的知识，并讨论它们如何与细胞死亡的分子机制成分相联系。
