McConkey D J, Orrenius S
Department of Cell Biology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
J Leukoc Biol. 1996 Jun;59(6):775-83.
The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanisms may also he involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeostasis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified. This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death.
从线虫秀丽隐杆线虫到人类，细胞凋亡受一组进化上保守的多肽调控，这表明一组保守的生化机制可能也参与了该反应。许多独立实验室的研究表明，胞质Ca2+ 稳态的改变是一种可能的机制，目前正在确定Ca2+ 的分子靶点。本综述将总结已知的Ca2+ 在细胞凋亡调控中的作用，并讨论Ca2+ 如何与其他一些涉及细胞死亡的生化信号相互作用。
