Anderson J, Clark R A, Watts D H, Till M, Arrastia C, Schuman P, Cohn S E, Young M, Bessen L, Greenblatt R, Vogler M, Swindells S, Boyer P
Johns Hopkins University, Baltimore Maryland, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):343-7. doi: 10.1097/00042560-199612010-00007.
A national survey of investigators caring for human immunodeficiency virus (HIV)-infected women was undertaken to describe the clinical presentation of idiopathic genital ulcer disease. Patients with negative syphilis and herpes simplex testing and/or negative genital ulcer biopsy were included in this study. Study participants (n = 29) were generally severely immunocompromised (median CD4 cell count was 50/mm3, and 68% had an acquired immunodeficiency syndrome [AIDS]-defining opportunistic process). Thirty-seven percent had coexistent oral ulcers and 19% had their genital ulcer progress to fistula formation (four rectovaginal and one vaginal-perineal). There was generally a favorable response to topical, systemic, and intralesional steroid treatment. This study suggests that idiopathic or probable aphthous genital ulcers in women have similar clinical characteristics to aphthous oroesophageal ulcers. Although infrequent, these genital ulcers can cause severe morbidity. Further research is warranted to better define the pathophysiology and optimal management.
针对负责照料感染人类免疫缺陷病毒（HIV）女性患者的研究人员开展了一项全国性调查，以描述特发性生殖器溃疡疾病的临床表现。梅毒和单纯疱疹检测呈阴性及/或生殖器溃疡活检呈阴性的患者被纳入本研究。研究参与者（n = 29）普遍免疫功能严重受损（CD4细胞计数中位数为50/mm³，68%患有获得性免疫缺陷综合征[艾滋病]界定的机会性疾病）。37%的患者同时患有口腔溃疡，19%的患者生殖器溃疡发展为瘘管形成（4例直肠阴道瘘和1例阴道会阴瘘）。局部、全身及病灶内注射类固醇治疗通常有良好疗效。本研究表明，女性特发性或可能的阿弗他生殖器溃疡与阿弗他食管溃疡具有相似的临床特征。尽管此类生殖器溃疡并不常见，但可导致严重发病。有必要开展进一步研究以更好地明确其病理生理学及最佳治疗方法。
