Bogaerts J, Kestens L, van Dyck E, Tello W M, Akingeneye J, Mukantabana V
Laboratory of Microbiology, Centre Hospitalier de Kigali, Belgo-Rwandan Medical Cooperation, Rwanda.
Int J STD AIDS. 1998 Nov;9(11):706-10. doi: 10.1258/0956462981921242.
During 1986-88 and 1990-92, 1025 (97%) out of 1057 genital ulcer patients in Kigali, Rwanda, were tested for HIV antibodies and for infection with Treponema pallidum, Haemophilus ducreyi and herpes simplex virus. Overall, 57% of men and 80% of women had antibodies to HIV-1. The most frequent laboratory diagnoses were chancroid (27%), syphilis (19%) and genital herpes (19%) among men and syphilis (35%), genital herpes (23%) and chancroid (20%) among women. HIV-1 seroprevalence increased sharply over time among men but not among women. The clinical presentation of ulcers as well as laboratory diagnoses were similar in the HIV-1 seropositive and seronegative groups. The relative frequency of all laboratory diagnoses remained unchanged over time. HIV-1 seropositivity had no impact on ulcer healing. Advanced immunodeficiency was diagnosed among 12% of the HIV-1 seropositive patients and was significantly associated with increasing age and genital herpes.
在1986 - 1988年以及1990 - 1992年期间，对卢旺达基加利1057名生殖器溃疡患者中的1025名（97%）进行了HIV抗体检测以及梅毒螺旋体、杜克雷嗜血杆菌和单纯疱疹病毒感染检测。总体而言，57%的男性和80%的女性有HIV - 1抗体。男性中最常见的实验室诊断为软下疳（27%）、梅毒（19%）和生殖器疱疹（19%），女性中为梅毒（35%）、生殖器疱疹（23%）和软下疳（20%）。随着时间推移，男性中HIV - 1血清阳性率急剧上升，而女性中则不然。HIV - 1血清阳性组和血清阴性组溃疡的临床表现以及实验室诊断相似。所有实验室诊断的相对频率随时间保持不变。HIV - 1血清阳性对溃疡愈合没有影响。在12%的HIV - 1血清阳性患者中诊断出晚期免疫缺陷，且其与年龄增长和生殖器疱疹显著相关。
