Okuda Y, Sone H, Mizutani S, Asano M, Tsurushima Y, Ogawa M, Tada K, Asakura Y, Kawakami Y, Suzuki S, Yamashita K
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
Prostaglandins. 1996 Nov;52(5):375-84. doi: 10.1016/s0090-6980(96)00102-5.
The acute effects of beraprost sodium (sodium (+/-)-(1R*, 2R, 3aS*, 8bS*)-2, 3, 3a 8b-tetrahydro-2-hydroxy-1-[(E)-(3S*)-3-hydroxy-4-methyl-I- octen-6-ynyl] -1H-cyclopenta [b] bensofuran-5-butyrate), a stable analogue of prostaglandin I2 which works as a vasodilator and anti-platelet agent, were investigated in patients with non-insulin dependent diabetes mellitus. Its effects on the dorsal pedis artery were examined using a new real-time two-dimensional Doppler ultrasonographic technique and by laser blood flowmetry. Before and 60 min after oral administration of beraprost sodium (Dolner 40 micrograms) and elastase (Elaszym 1800 U), the cross-sectional area (CSA) of the dorsal pedis artery and its blood flow index (BFI), calculated from the maximum flow velocity and area, were determined. Dermal microcirculatory blood volume (MBV) was also measured by laser blood flowmetry. In the beraprost sodium group, the CSA, BFI and MBV were significantly increased, while in the elastase group, no significant changes were observed. These result suggest that beraprost sodium has a beneficial effect on diabetic macro- and microangiopathy.
贝前列素钠（(+/-)-(1R*, 2R, 3aS*, 8bS*)-2, 3, 3a, 8b-四氢-2-羟基-1-[(E)-(3S*)-3-羟基-4-甲基-1-辛烯-6-炔基]-1H-环戊[b]苯并呋喃-5-丁酸钠）是一种前列腺素I2的稳定类似物，具有血管舒张和抗血小板作用。本研究在非胰岛素依赖型糖尿病患者中探讨了其急性效应。采用一种新的实时二维多普勒超声技术和激光血流测定法，检测其对足背动脉的影响。口服贝前列素钠（德纳40微克）和弹性蛋白酶（弹力酶1800单位）前及服药后60分钟，测定足背动脉的横截面积（CSA）及其血流指数（BFI，由最大流速和面积计算得出）。同时用激光血流测定法测量皮肤微循环血容量（MBV）。在贝前列素钠组中，CSA、BFI和MBV显著增加，而在弹性蛋白酶组中未观察到显著变化。这些结果表明，贝前列素钠对糖尿病大血管和微血管病变具有有益作用。
