Inagaki O, Syono T, Nakagawa K, Nishian Y, Takenaka Y, Takamitsu Y
Department of Kidney and Dialysis, Hyogo College of Medicine, Japan.
Ren Fail. 1996 Nov;18(6):847-54. doi: 10.3109/08860229609047711.
The influence of magnesium (Mg) deficiency on the concentration of calcium (Ca) in the aorta, heart, and kidney was evaluated in uremic rats. A total of 32 rats were randomly assigned to two groups: one group made uremic by the 5/6 nephrectomy method, and the other serving as sham-operated controls. Both groups were randomly assigned to two subgroups: one group given a Mg-deficient diet and the other fed a Mg-supplemented diet. After 12 weeks on the regimen, all animals were sacrificed. In Mg-supplemented uremic rats, the concentration of Ca in the aorta was higher than in Mg-supplemented control rats. The concentration of Ca in the aorta was further increased in Mg-deficient uremic rats. The concentrations of Ca in the heart and the kidney were also increased in Mg-deficient uremic rats, as compared with Mg-supplemented uremic rats. The concentration of Mg was decreased in the aorta and increased in the kidney of Mg-deficient rats. There was no significant influence of Mg deficiency on the concentration of phosphate in tissue. Results suggest that Mg deficiency in uremia may increase aortic calcification.
在尿毒症大鼠中评估了镁（Mg）缺乏对主动脉、心脏和肾脏中钙（Ca）浓度的影响。总共32只大鼠被随机分为两组：一组通过5/6肾切除术法制成尿毒症大鼠，另一组作为假手术对照组。两组又被随机分为两个亚组：一组给予缺镁饮食，另一组给予补充镁的饮食。在该方案实施12周后，所有动物均被处死。在补充镁的尿毒症大鼠中，主动脉中的钙浓度高于补充镁的对照大鼠。在缺镁的尿毒症大鼠中，主动脉中的钙浓度进一步升高。与补充镁的尿毒症大鼠相比，缺镁的尿毒症大鼠心脏和肾脏中的钙浓度也升高。缺镁大鼠的主动脉中镁浓度降低，肾脏中镁浓度升高。镁缺乏对组织中磷酸盐浓度没有显著影响。结果表明，尿毒症中的镁缺乏可能会增加主动脉钙化。
