Inagaki O, Shono T, Nakagawa K, Gomikawa S, Mori H, Fujita Y
Dialysis Unit, Hyogo College of Medicine, Nishinomiya, Japan.
Nephron. 1990;55(2):176-80. doi: 10.1159/000185948.
The effects of acute magnesium deficiency on lipid metabolism were examined in five-sixths nephrectomized uremic rats and sham-operated rats. Three weeks after the surgery, both groups were divided into two subgroups. Half of the uremic and sham-operated rats received a magnesium-deficient diet. The rest of the experimental animals received a control diet. After 2 weeks on this regimen, all animals were sacrificed. In uremic rats, magnesium deficiency increased serum triglyceride levels and decreased high-density lipoprotein cholesterol levels as in sham-operated rats. Total serum cholesterol levels were higher in uremic rats than in sham-operated rats with or without magnesium deficiency. Serum free fatty acid levels were increased only in uremic rats with magnesium deficiency. These results suggest that magnesium deficiency worsens several parameters of lipid in uremic rats.
在切除六分之五肾脏的尿毒症大鼠和假手术大鼠中研究了急性镁缺乏对脂质代谢的影响。手术后三周，两组均分为两个亚组。一半的尿毒症大鼠和假手术大鼠接受缺镁饮食。其余实验动物接受对照饮食。在该饮食方案持续2周后，处死所有动物。与假手术大鼠一样，在尿毒症大鼠中，镁缺乏会增加血清甘油三酯水平并降低高密度脂蛋白胆固醇水平。无论有无镁缺乏，尿毒症大鼠的总血清胆固醇水平均高于假手术大鼠。仅在缺镁的尿毒症大鼠中血清游离脂肪酸水平升高。这些结果表明，镁缺乏会使尿毒症大鼠的多项脂质参数恶化。
