Moran C J, Neely J G
George Englemann Mathematics & Science Institute Scholar Research Program, Washington University School of Medicine, St. Louis, MO, USA.
Laryngoscope. 1996 Dec;106(12 Pt 1):1491-6. doi: 10.1097/00005537-199612000-00009.
Facial nerve synkinesis is an extremely distressing sequela of facial paralysis, and its prevention and treatment are less than adequate. Improved therapeutic interventions await better understanding of its pathogenesis. In this study, 11 patients with synkinesis and 11 normal control subjects were quantitatively assessed using a new computer-assisted, motion-sensitive system. Two additional, informative cases presenting at the completion of the study are also briefly reported. The observed synkinetic patterns appear predictable and nonrandom. In addition, these observations tend to raise doubts that the aberrant fiber regeneration hypothesis is the sole explanation of synkinesis. They further implicate facial nuclear hyperexcitability as an explanation in at least some cases of synkinesis. Understanding these patterns enhances clinical detection and evaluation and may lead to a better knowledge of the fundamental pathophysiology of synkinesis and its prevention.
面神经联动是面瘫极为令人苦恼的后遗症，其预防和治疗尚不完善。改进治疗干预措施有待更好地了解其发病机制。在本研究中，使用一种新的计算机辅助运动敏感系统对11例联动患者和11名正常对照者进行了定量评估。还简要报告了在研究结束时出现的另外两个有参考价值的病例。观察到的联动模式似乎具有可预测性且并非随机出现。此外，这些观察结果往往使人怀疑异常纤维再生假说是联动的唯一解释。它们进一步表明，至少在某些联动病例中，面神经核的过度兴奋性是一种解释。了解这些模式有助于临床检测和评估，并可能使人更好地了解联动的基本病理生理学及其预防。
