Garcia-B C Q, Baez-Vasquez B, Rodriguez-Colorado S
la Unidad de Toco-Cirugía, Instituto Nacional de Perinatología, México.
Ginecol Obstet Mex. 1996 Jan;64:21-5.
A comparative study was undertaken to evaluate the effect of a single dose of 0.5 mg of PGE2 on the uterine cervix and the subsequent progress of labor induction, from february 1992 to december 1993 in The Instituto Nacional de Perinatología. The obstetric results obtained from women with antepartum fetal death, were divided in two groups: group A women between 21 to 27 weeks gestation, group B from 28-36 weeks gestation, and a control group without PGE2 aplication. Dinoprostone 0.5 mg in a new gel form given intracervically in a single dose. In Group A induction-to-delivery interval were about 12 h compared with the control group about 24 h, this difference is statistically significant (P < 0.001). In Group B induction-to-delivery interval were about 9 h, and a control group about 16.5 h, this difference is satistically significant (P < 0.001). In conclusion, the PGE2 (dinoprostone 0.5 mg) in gel, is a drug with high effectiveness when used for labor preinduction as applied in this study.
1992年2月至1993年12月，在国家围产医学研究所进行了一项比较研究，以评估单剂量0.5毫克前列腺素E2（PGE2）对子宫颈的影响以及随后引产的进展情况。将产前胎儿死亡女性的产科结果分为两组：A组为妊娠21至27周的女性，B组为妊娠28至36周的女性，还有一个未应用PGE2的对照组。以新凝胶形式将0.5毫克地诺前列酮宫颈内单剂量给药。A组引产至分娩间隔约为12小时，而对照组约为24小时，这一差异具有统计学意义（P < 0.001）。B组引产至分娩间隔约为9小时，对照组约为16.5小时，这一差异具有统计学意义（P < 0.001）。总之，本研究应用的凝胶形式的PGE2（0.5毫克地诺前列酮）用于引产时是一种高效药物。
