肾脏对磷缺乏的反应：甲状旁腺和碳酸氢盐的作用。

Renal response to phosphorus deprivation: effect of the parathyroids and bicarbonate.

作者信息

Steele T H

出版信息

Kidney Int. 1977 May;11(5):327-34. doi: 10.1038/ki.1977.50.

DOI:10.1038/ki.1977.50

Abstract

Plasma inorganic phosphate (Pi) and Pi reabsorption were compared in intact and chronically thyroparathyroidectomized (TPTX) rats stabilized on a high or low-phosphorus diet after volume expansion with equivalent sodium bicarbonate or sodium chloride. Phosphate infusion after sodium chloride-loading resulted in greater hyperphosphatemia and diminished phosphaturia in TPTX rats than intact high-phosphorus rats. After sodium bicarbonate-loading, however, there was no difference between intact and TPTX high-phosphorus animals because bicarbonate inhibited Pi reabsorption extensively in both. In contrast, phosphate infusion after sodium chloride-loading in phosphorus-deprived rats elicited greater degrees of hyperphosphatemia and increased Pi reabsorption, irrespective of the presence or absence of the parathyroids. Sodium bicarbonate-loading inhibited Pi reabsorption significantly less in phosphorus-deprived rats than in high-phosphorus animals. Paradoxically, this inhibitory effect of bicarbonate in phosphorus depletion was greater in TPTX rats than in intact animals. Therefore, the presence of the parathyroids did not interfere with Pi reabsorption during phosphate infusion in sodium bicarbonate-loaded phosphorus-deprived rats. Sodium bicarbonate-loading interfered with Pi reabsorption most prominently in phosphorus-deprived rats when the parathyroids were absent.

摘要

在通过等量碳酸氢钠或氯化钠进行容量扩张后，对维持高磷或低磷饮食的完整大鼠以及慢性甲状旁腺切除（TPTX）大鼠的血浆无机磷酸盐（Pi）和Pi重吸收进行了比较。与完整的高磷大鼠相比，TPTX大鼠在输注氯化钠后进行磷酸盐输注时，会导致更严重的高磷血症和磷尿减少。然而，在输注碳酸氢钠后，完整大鼠和TPTX高磷动物之间没有差异，因为碳酸氢钠在两者中均广泛抑制Pi重吸收。相比之下，在缺磷大鼠中输注氯化钠后进行磷酸盐输注，无论有无甲状旁腺，都会引发更高程度的高磷血症并增加Pi重吸收。碳酸氢钠负荷对缺磷大鼠Pi重吸收的抑制作用明显小于高磷动物。矛盾的是，碳酸氢钠在磷缺乏时的这种抑制作用在TPTX大鼠中比在完整动物中更大。因此，甲状旁腺的存在并不干扰在输注碳酸氢钠的缺磷大鼠中进行磷酸盐输注期间的Pi重吸收。当甲状旁腺缺失时，碳酸氢钠负荷对缺磷大鼠Pi重吸收的干扰最为显著。