Friston K J
Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK.
Br Med Bull. 1996 Jul;52(3):644-55. doi: 10.1093/oxfordjournals.bmb.a011573.
This chapter addresses the idea that schizophrenia is a 'disconnection syndrome' from a theoretical and computational perspective. The distinction between anatomical and functional connectivity is reviewed and used as a framework to introduce empirical and computational evidence that schizophrenia involves, at some level, a disintegration of neuronal interactions. The chapter concludes with an example of computational neuroscience that relates observations on the dimensional complexity of neuronal dynamics in schizophrenia to the disconnection hypothesis.
本章从理论和计算的角度探讨了精神分裂症是一种“脱节综合征”的观点。回顾了解剖连接和功能连接之间的区别，并将其作为一个框架，用以介绍实证和计算证据，即精神分裂症在某种程度上涉及神经元相互作用的瓦解。本章最后给出了一个计算神经科学的例子，该例子将精神分裂症中神经元动力学维度复杂性的观察结果与脱节假说联系起来。
