Ferri C, Bellini C, Desideri G, Di Francesco L, De Mattia G, Santucci A
Institut de I Clinica Medica, Université La Sapienza, Rome, Italie.
Arch Mal Coeur Vaiss. 1996 Aug;89(8):971-4.
Plasma endothelin-1 (ET-1) and von Willebrand factor (vWF) levels are elevated in the presence of either macro- or microvascular lesions. Since an increased risk to develop hypertension-related vascular damage has been suggested in human sensitive hypertension, we evaluated both substances in plasma samples from 20 non-diabetic, non obese essential hypertensive men (mean age 49 +/- 4 years). Patients were divided in salt sensitive (n = 9) or salt resistant (n = 11) groups, according to the individual response to both high- and low-sodium diets. Plasma ET-1 levels were also assessed after an oral glucose tolerance test (75 g). Both ET-1 and vWF were higher in salt sensitive than salt resistant patients (ET-1 p < 0.01; vWF p < 0.03). Furthermore, after oral glucose administration, plasma ET-1 concentrations increased very mildly but significantly only in salt sensitive patients (p < 0.05 at 90 min). In conclusion, human salt sensitive hypertension is combined to increased levels of two markers of endothelial damage, and by an augmented ET-1 response to glucose leading, suggesting it is characterized by an increased risk to develop hypertension-related vascular complications.
在存在大血管或微血管病变的情况下，血浆内皮素-1（ET-1）和血管性血友病因子（vWF）水平会升高。由于在人类敏感性高血压中已表明发生高血压相关血管损伤的风险增加，我们评估了20名非糖尿病、非肥胖原发性高血压男性（平均年龄49±4岁）血浆样本中的这两种物质。根据个体对高钠和低钠饮食的反应，将患者分为盐敏感组（n = 9）和盐抵抗组（n = 11）。在口服葡萄糖耐量试验（75克）后也评估了血浆ET-1水平。盐敏感患者的ET-1和vWF水平均高于盐抵抗患者（ET-1 p < 0.01；vWF p < 0.03）。此外，口服葡萄糖后，仅盐敏感患者的血浆ET-1浓度有非常轻微但显著的升高（90分钟时p < 0.05）。总之，人类盐敏感性高血压与内皮损伤的两种标志物水平升高相关，并且对葡萄糖的ET-1反应增强，这表明其特征是发生高血压相关血管并发症的风险增加。
