Möller H, Björkner B, Bruze M
Department of Dermatology, Malmö University Hospital, Sweden.
Br J Dermatol. 1996 Sep;135(3):423-7.
In a double blind experimental study, 20 patients with a contact allergy to gold sodium thiosulphate were challenged intramuscularly with the chemically similar gold sodium thiomalate and with placebo. The most spectacular clinical reaction in the 10 patients given the active agent, was an epidermal and dermal flare up of healed patch-test reactions to the gold salts, as well as a high, but transient, rise in body temperature. Previous intradermal tests were similarly reactivated. In addition, toxicoderma-like rashes were observed in several cases, but a flare up of a previous contact dermatitis site was seen in one patient only. The specificity of the positive provocations was demonstrated.
在一项双盲实验研究中，对20名对硫代硫酸钠金钠有接触性过敏的患者进行肌肉注射化学性质相似的硫代苹果酸金钠和安慰剂激发试验。在接受活性剂的10名患者中，最显著的临床反应是对金盐的愈合斑贴试验反应出现表皮和真皮炎症，以及体温急剧但短暂升高。先前的皮内试验也类似地被重新激活。此外，在几例患者中观察到中毒性皮疹样皮疹，但仅在一名患者中出现先前接触性皮炎部位的炎症。证实了阳性激发试验的特异性。
