de Sequera P, Albalate M, Hernandez J, Vazquez A, Abad J, Ramiro E, Fernández Guerrero M, Caramelo C, Casado S, Ortiz A
Nephrology Service, Fundación Jiménez Díaz, Madrid, Spain.
Postgrad Med J. 1996 Sep;72(851):557-8. doi: 10.1136/pgmj.72.851.557.
We report two AIDS patients who developed acute renal failure while receiving sulphadiazine for cerebral toxoplasmosis. Renal ultrasound revealed diffuse bilateral echogenic shadowing material. 'Sheaves of wheat' crystals, typical of sulphadiazine crystalluria, were present in the urine. One patient required a percutaneous nephrostomy. Hydration and urine alkalinisation resulted in rapid improvement of renal function and ultrasonographic findings. Sulphadiazine-induced crystalluria and acute renal failure is increasingly frequent. Awareness of its existence may lead to prevention and early conservative treatment.
我们报告了两名艾滋病患者，他们在接受磺胺嘧啶治疗脑弓形虫病时出现了急性肾衰竭。肾脏超声显示双侧弥漫性回声阴影物质。尿液中存在磺胺嘧啶结晶尿典型的“麦秸束”晶体。一名患者需要进行经皮肾造瘘术。补液和尿液碱化使肾功能和超声检查结果迅速改善。磺胺嘧啶引起的结晶尿和急性肾衰竭越来越常见。认识到其存在可能有助于预防和早期保守治疗。
