小于胎龄儿的低骨矿物质密度：与脐血锌浓度的相关性
Low bone mineral density in small for gestational age infants: correlation with cord blood zinc concentrations.
作者信息
Chunga Vega F, Gómez de Tejada M J, González Hachero J, Pérez Cano R, Coronel Rodriguez C
机构信息
Department of Paediatrics, University Hospital, Virgen Macarena, Seville, Spain.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1996 Sep;75(2):F126-9. doi: 10.1136/fn.75.2.f126.
Twenty eight term small for gestational age (SGA) infants and 18 term appropriate for gestational age (AGA) infants were studied prospectively to assess bone mineral density and cord serum zinc concentrations. Growth and nutritional status were evaluated, and bone mineral density was measured by dual energy x ray densitometry of the lumbar spine. Cord serum zinc, parathyroid hormone, osteocalcin, vitamin D metabolite and mineral concentrations were measured. Growth, nutritional status, and bone mineral density (mean (SD) 0.223 (0.032) vs 0.277 (0.032) g hydroxyapatite/cm2) were significantly low in SGA infants. Bone mineral density was linearly related to growth and nutritional measures. Cord serum zinc concentrations were in the normal range and similar in both groups (mean (SD) 13.86 (3.0) vs 13.43 (2.1) mumol/l). It is suggested that SGA infants may not be zinc deficient. Low bone mineral density could be caused by growth and nutritional status deficiencies, the mechanisms for which could be those that reduce nutrient substrate supply to the fetus.
对28名足月小于胎龄（SGA）婴儿和18名足月适于胎龄（AGA）婴儿进行了前瞻性研究，以评估骨矿物质密度和脐血血清锌浓度。评估了生长和营养状况，并通过腰椎双能X线骨密度仪测量骨矿物质密度。测量了脐血血清锌、甲状旁腺激素、骨钙素、维生素D代谢产物和矿物质浓度。SGA婴儿的生长、营养状况和骨矿物质密度（平均值（标准差）0.223（0.032）对0.277（0.032）g羟磷灰石/cm2）显著较低。骨矿物质密度与生长和营养指标呈线性相关。两组脐血血清锌浓度均在正常范围内且相似（平均值（标准差）13.86（3.0）对13.43（2.1）μmol/l）。提示SGA婴儿可能不存在锌缺乏。低骨矿物质密度可能由生长和营养状况不足引起，其机制可能是减少了对胎儿的营养底物供应。
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