Dwivedi C, Abu-Ghazaleh A, Guenther J
College of Pharmacy, South Dakota State University, Brookings 57007, USA.
Anticancer Drugs. 1996 Sep;7(7):792-4. doi: 10.1097/00001813-199609000-00012.
The effects of diallyl sulfide (DAS) and diallyl disulfide (DADS) on cisplatin-induced changes in glutathione (GSH) and glutathione-S-transferase (GST) activity in rat liver and kidney was investigated. Cisplatin treatment significantly (p < 0.05) decreased GSH and GST activity in both liver and kidney. DADS treatment significantly (p < 0.05) enhanced GSH and GST activity in rat liver and kidney. Furthermore, DADS treatment reversed the effect of cisplatin on GSH and GST activity both in liver and kidney. Administration of DADS with cisplatin could enhance GSH and GST activity and lower cisplatin-induced nephrotoxicity.
研究了二烯丙基硫醚（DAS）和二烯丙基二硫醚（DADS）对顺铂诱导的大鼠肝脏和肾脏中谷胱甘肽（GSH）及谷胱甘肽 - S - 转移酶（GST）活性变化的影响。顺铂处理显著（p < 0.05）降低了肝脏和肾脏中的GSH及GST活性。DADS处理显著（p < 0.05）增强了大鼠肝脏和肾脏中的GSH及GST活性。此外，DADS处理逆转了顺铂对肝脏和肾脏中GSH及GST活性的影响。DADS与顺铂联合给药可增强GSH及GST活性，并降低顺铂诱导的肾毒性。
