血管紧张素II通过作用于AT1受体，可能会调节内皮素-1在清醒大鼠中的行为效应。

Angiotensin II, via an action at AT1 receptors, may modulate the behavioural effects of ET-1 in conscious rats.

作者信息

D'Amico M, di Filippo C, Berrino L, Rossi F

机构信息

Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, 2nd University of Naples, Italy.

出版信息

Life Sci. 1996;59(22):PL355-8. doi: 10.1016/s0024-3205(96)00541-3.

DOI:10.1016/s0024-3205(96)00541-3

PMID:8950291

Abstract

The injection of endothelin-1 (ET-1) (1 pmol/rat) into the dorsolateral periaqueductal gray (PAG) area of freely moving rats induced rotation along the long axis of the body (barrel-rolling). Preinjection (10 min before) of losartan (a selective AT1 receptor antagonist; 50 nmol) to the PAG area reduced the behavioural response to ET-1. In contrast, pretreatment with PD123319 (a selective AT2 receptor antagonist; 50 nmol) did not affect the ET-1-induced barrel-rolling. These results indicate that endogenous angiotensin II, via an action on AT1 receptors, contributes to the barrel-rolling of ET-1 within the brain.

摘要

向自由活动大鼠的背外侧导水管周围灰质（PAG）区域注射内皮素-1（ET-1）（1 pmol/大鼠）会诱导大鼠沿身体长轴旋转（翻滚）。在向PAG区域注射洛沙坦（一种选择性AT1受体拮抗剂；50 nmol）之前（提前10分钟）进行预注射，可降低对ET-1的行为反应。相比之下，用PD123319（一种选择性AT2受体拮抗剂；50 nmol）进行预处理并不影响ET-1诱导的翻滚。这些结果表明，内源性血管紧张素II通过作用于AT1受体，在大脑中促成了ET-1诱导的翻滚。