Imamura Y, Takada H, Kimura R, Mori Y, Otagiri M
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Life Sci. 1996;59(25-26):2201-8. doi: 10.1016/s0024-3205(96)00577-2.
The inheritance patterns of acetohexamide reductase activities in liver microsomes and cytosol of rats were determined by using the inbred Wistar-Imamichi and Fischer-344 strains as a model of low and high metabolizers, respectively. A simple Mendelian genetic analysis for the frequency distribution of acetohexamide reductase activity in liver microsomes of male rats led us to conclude that the phenotype is genetically regulated by an autosomal co-dominant fashion. Female rats, unlike male rats, did not exhibit microsomal enzyme activity in parental, first filial (F1) and second filial (F2) generations, indicating that the inheritance of the microsomal enzyme activity is sex-limited. On the other hand, the frequency distribution of acetohexamide reductase activities in liver cytosol of male and female rats was unimodal in all generations and there was no significant difference among these cytosolic enzyme activities.
分别以近交系Wistar-Imamichi和Fischer-344大鼠作为低代谢者和高代谢者的模型，测定大鼠肝脏微粒体和胞质中醋磺己脲还原酶活性的遗传模式。对雄性大鼠肝脏微粒体中醋磺己脲还原酶活性的频率分布进行简单的孟德尔遗传分析后，我们得出结论，该表型由常染色体共显性方式进行遗传调控。与雄性大鼠不同，雌性大鼠在亲代、第一代（F1）和第二代（F2）中均未表现出微粒体酶活性，这表明微粒体酶活性的遗传具有性别局限性。另一方面，雄性和雌性大鼠肝脏胞质中醋磺己脲还原酶活性的频率分布在所有世代中均为单峰，且这些胞质酶活性之间无显著差异。
