Regnery R L, Rooney J A, Johnson A M, Nesby S L, Manzewitsch P, Beaver K, Olson J G
Viral and Rickettsial Zoonoses Branch, US Department of Health and Human Services, Atlanta, GA 30333, USA.
Am J Vet Res. 1996 Dec;57(12):1714-9.
To elucidate kinetics of Bartonella henselae bacteremia and IgG response, evaluate antibiotic therapy, and investigate challenge exposure in cats.
Specific-pathogen-free cats.
Cats were inoculated with B henselae or B quintana and monitored. Convalescent cats were challenge exposed with B henselae. Amoxicillin, enrofloxacin, erythromycin, and tetracycline HCl were evaluated for effect on B henselae bacteremia.
Cats developed B henselae bacteremia within 1 week; bacteremia persisted for longer than 2 months before subsiding spontaneously. IgG antibody titer developed shortly after onset of bacteremia; antibody co-existed with bacteremia for several weeks and remained detectable after bacteremia subsided. Cats inoculated with B quintana remained abacteremic. On challenge exposure to B henselae, cats previously infected with B henselae remained abacteremic; cats previously inoculated with B quintana supported B henselae infection. Tetracycline HCl and erythromycin depressed B henselae bacteremia; however, duration of bacteremia remained similar to that in untreated cats. Obvious signs of illness were not observed.
Long-duration, high-titer B henselae infections were highly reproducible in cats. Convalescent cats were immune to reinfection. B quintana-inoculated cats did not have evidence of infection and were susceptible to B henselae challenge exposure. Antibiotic therapy was incompletely efficacious in terminating cat bacteremia.
A cat with an inapparent B henselae infection must provisionally be regarded as a possible reservoir for infection for a minimum of 2 to 3 months. Convalescent cats are resistant to reinfection. Usual antibiotic therapy was not completely efficacious. Measurement of IgG antibody can be used to detect past or current infection.
阐明亨氏巴尔通体菌血症的动力学及IgG反应，评估抗生素治疗效果，并研究猫的激发暴露情况。
无特定病原体猫。
给猫接种亨氏巴尔通体或五日热巴尔通体并进行监测。对恢复期的猫进行亨氏巴尔通体激发暴露。评估阿莫西林、恩诺沙星、红霉素和盐酸四环素对亨氏巴尔通体菌血症的影响。
猫在1周内出现亨氏巴尔通体菌血症；菌血症持续超过2个月后自行消退。IgG抗体滴度在菌血症发作后不久出现；抗体与菌血症共存数周，菌血症消退后仍可检测到。接种五日热巴尔通体的猫未出现菌血症。在激发暴露于亨氏巴尔通体时，先前感染过亨氏巴尔通体的猫未出现菌血症；先前接种过五日热巴尔通体的猫出现了亨氏巴尔通体感染。盐酸四环素和红霉素可抑制亨氏巴尔通体菌血症；然而，菌血症持续时间与未治疗的猫相似。未观察到明显的疾病迹象。
猫可高度重复出现长时间、高滴度的亨氏巴尔通体感染。恢复期的猫对再次感染具有免疫力。接种五日热巴尔通体的猫没有感染证据，且易受亨氏巴尔通体激发暴露感染。抗生素治疗在终止猫的菌血症方面效果不完全。
一只患有隐匿性亨氏巴尔通体感染的猫在至少2至3个月内必须暂时被视为可能的感染源。恢复期的猫对再次感染具有抵抗力。常规抗生素治疗效果不完全。检测IgG抗体可用于检测既往或当前感染。
