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猫巴尔通体心内膜炎的成功治疗

Successful treatment of Bartonella henselae endocarditis in a cat.

作者信息

Perez Cristina, Hummel James B, Keene Bruce W, Maggi Ricardo G, Diniz Pedro P V P, Breitschwerdt Edward B

机构信息

Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University (NCSU), Raleigh, NC, United States.

出版信息

J Feline Med Surg. 2010 Jun;12(6):483-6. doi: 10.1016/j.jfms.2009.12.018. Epub 2010 Feb 6.

DOI:10.1016/j.jfms.2009.12.018
PMID:20138559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10822285/
Abstract

This report describes the clinical presentation, diagnosis and treatment of a cat with vegetative valvular endocarditis temporally associated with natural infection with Bartonella henselae. Lethargy, abnormal gait and weakness were the main clinical signs that resulted in referral for diagnostic evaluation. Using a novel and sensitive culture approach, B henselae was isolated from the blood. Following antibiotic therapy there was total resolution of clinical signs, the heart murmur, the valvular lesion by echocardiography, and no Bartonella species was isolated or amplified from a post-treatment blood culture. In conjunction with previous case reports, infective endocarditis can be associated with natural B henselae infection in cats; however, early diagnosis and treatment may result in a better prognosis than previously reported.

摘要

本报告描述了一只猫患增殖性心内膜炎的临床表现、诊断及治疗情况,该病与感染汉氏巴尔通体自然感染存在时间上的关联。嗜睡、异常步态和虚弱是导致转诊进行诊断评估的主要临床症状。采用一种新颖且灵敏的培养方法,从血液中分离出了汉氏巴尔通体。抗生素治疗后,临床症状、心脏杂音、超声心动图显示的瓣膜病变均完全消失,且治疗后血培养未分离或扩增出任何巴尔通体菌种。结合之前的病例报告,感染性心内膜炎可能与猫自然感染汉氏巴尔通体有关;然而,早期诊断和治疗可能会带来比之前报道更好的预后。

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本文引用的文献

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Bartonella endocarditis: a pathology shared by animal reservoirs and patients.巴尔通体心内膜炎:动物宿主与患者共有的一种病理状况。
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Feline bartonellosis and cat scratch disease.猫巴尔通体病和猫抓病
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A combined approach for the enhanced detection and isolation of Bartonella species in dog blood samples: pre-enrichment liquid culture followed by PCR and subculture onto agar plates.一种用于增强犬血样中巴通体属物种检测和分离的联合方法:先进行预富集液体培养,然后进行PCR并转接至琼脂平板上进行继代培养。
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Bartonella spp. in pets and effect on human health.宠物身上的巴尔通体属细菌及其对人类健康的影响。
Emerg Infect Dis. 2006 Mar;12(3):389-94. doi: 10.3201/eid1203.050931.
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Novel chemically modified liquid medium that will support the growth of seven bartonella species.能够支持七种巴尔通体菌种生长的新型化学修饰液体培养基。
J Clin Microbiol. 2005 Jun;43(6):2651-5. doi: 10.1128/JCM.43.6.2651-2655.2005.
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Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis.柯氏巴尔通体,一种与猫相关的新型人类血培养阴性心内膜炎病原体。
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A prospective study of canine infective endocarditis in northern California (1999-2001): emergence of Bartonella as a prevalent etiologic agent.加利福尼亚北部犬感染性心内膜炎的前瞻性研究(1999 - 2001年):巴尔通体作为主要病原体的出现
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