Vacchio M S, King L B, Ashwell J D
Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20852, USA.
Behring Inst Mitt. 1996 Oct(97):24-31.
It is generally believed that the avidity of the T cell receptor for self antigen/MHC determines the fate of a thymocyte. However, it is not understood how the thymocyte distinguishes a survival signal (positive selection) from a death signal (negative selection). Recent studies from our laboratory have explored the role that thymus-produced glucocorticoids may play in influencing thymocyte development. It appears that glucocorticoids are important and necessary at several points during thymocyte differentiation and that they may regulate antigen-specific T cell development.
一般认为，T细胞受体对自身抗原/MHC的亲和力决定了胸腺细胞的命运。然而，尚不清楚胸腺细胞如何区分存活信号（阳性选择）和死亡信号（阴性选择）。我们实验室最近的研究探讨了胸腺产生的糖皮质激素在影响胸腺细胞发育中可能发挥的作用。糖皮质激素似乎在胸腺细胞分化的几个阶段都很重要且必不可少，并且它们可能调节抗原特异性T细胞的发育。
