非β-内酰胺类抗菌药物的最低抑菌浓度（MIC）作为区分表皮葡萄球菌对苯唑西林耐药菌株和敏感菌株的标志物的效用。

The utility of non-beta-lactam antimicrobial MICs as markers to distinguish oxacillin-resistant from oxacillin-susceptible strains of Staphylococcus epidermidis.

作者信息

Fass R J, Barnishan J, Ayers L W

机构信息

Department of Internal Medicine, Ohio State University Medical Center, Columbus, USA.

出版信息

Diagn Microbiol Infect Dis. 1996 Sep;26(1):43-5. doi: 10.1016/s0732-8893(96)00163-0.

DOI:10.1016/s0732-8893(96)00163-0

PMID:8950529

Abstract

Among 6,068 strains of Staphylococcus epidermidis, 75.5% were oxacillin-resistant. Oxacillin-susceptible strains were more frequently susceptible to erythromycin, clindamycin, ciprofloxacin, trimethoprim/sulfamethoxazole, gentamicin, and tetracycline than oxacillin-resistant strains. With the exception of erythromycin, non-beta-lactam MICs were less discriminatory for identifying oxacillin-resistant strains with oxacillin MICs < or = 2 micrograms/ml than for those with oxacillin MICs > or = 4 micrograms/ml.

摘要

在6068株表皮葡萄球菌中，75.5%对苯唑西林耐药。苯唑西林敏感菌株比苯唑西林耐药菌株更易对红霉素、克林霉素、环丙沙星、甲氧苄啶/磺胺甲噁唑、庆大霉素和四环素敏感。除红霉素外，对于苯唑西林MIC≤2微克/毫升的苯唑西林耐药菌株，非β-内酰胺类药物的MIC在鉴别方面不如苯唑西林MIC≥4微克/毫升的菌株有区分度。